| Primary information |
|---|
| ID | 17290 |
| Uniprot ID | O95760 |
| Description | Interleukin-33 (IL-33) (Interleukin-1 family member 11) (IL-1F11) (Nuclear factor from high endothelial venules) (NF-HEV) [Cleaved into- Interleukin-33 (95-270); Interleukin-33 (99-270); Interleukin-33 (109-270)] |
| Organism | Homo sapiens |
| Txonomy | Eukaryota; Opisthokonta; Metazoa; Eumetazoa; Bilateria; Deuterostomia; Chordata; Craniata; Vertebrata; Gnathostomata (jawed vertebrates); Teleostomi; Euteleostomi; Sarcopterygii; Dipnotetrapodomorpha; Tetrapoda; Amniota; Mammalia; Theria; Eutheria; Boreoeutheria; Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini; Hominoidea (apes); Hominidae (great apes); Homininae; Homo; Homo sapiens (Human) |
| Subcellular Location | Nucleus |
| Developmental Stage | NA |
| Similarity | NA |
| Tissue Specificity | Expressed at high level in high endothelial venules found in tonsils; Peyer patches and mesenteric lymph nodes. Almost undetectable in placenta. |
| Post Translational Modification | The full-length protein can be released from cells and is able to signal via the IL1RL1/ST2 receptor. However; proteolytic processing by CSTG/cathepsin G and ELANE/neutrophil elastase produces C-termi |
| Function | Cytokine that binds to and signals through the IL1RL1/ST2 receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells |
| Length | 270 |
| Molecular Weight | 30759 |
| Name | Interleukin-33 |
| Sequence | KPKMKYSTNKISTAKWKNTASKALCFKLGKSQQKAKEVCPMYFMKLRSGLMIKKEACYFRRETTKRPSLKTGRKHKRHLVLAACQQQSTVECFAFGISGVQKYTRALHDSSITGISPITEYLASLSTYNDQSITFALEDESYEIYVEDLKKDEKKDKVLLSYYESQHPSNESGDGVDGKMLMVTLSPTKDFWLHANNKEHSVELHKCEKPLPDQAFFVLHNMHSNCVSFECKTDPGVFIGVKDNHLALIKVDSSENLCTENILFKLSET |
| Sequence map | 5-30 |
| PDB ID | NA |
| Drugpedia | NA |
| Receptor | Q01638 |
| Domain | The homeodomain-like HTH domain mediates nuclear l |
| Pharmaceutical Use | NA
|