Detailed description page of Hmrbase2

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17281 details
Primary information
ID17281
Uniprot IDP60568
DescriptionInterleukin-2 (IL-2) (T-cell growth factor) (TCGF) (Aldesleukin)
OrganismHomo sapiens
TxonomyEukaryota; Opisthokonta; Metazoa; Eumetazoa; Bilateria; Deuterostomia; Chordata; Craniata; Vertebrata; Gnathostomata (jawed vertebrates); Teleostomi; Euteleostomi; Sarcopterygii; Dipnotetrapodomorpha; Tetrapoda; Amniota; Mammalia; Theria; Eutheria; Boreoeutheria; Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini; Hominoidea (apes); Hominidae (great apes); Homininae; Homo; Homo sapiens (Human)
Subcellular LocationSecreted
Developmental StageNA
SimilarityNA
Tissue SpecificityNA
Post Translational ModificationNA
FunctionCytokine produced by activated CD4-positive helper T-cells and to a lesser extend activated CD8-positive T-cells and natural killer (NK) cells that plays pivotal roles in the immune response and tolerance
Length153
Molecular Weight17628
NameInterleukin-2
SequencePTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT
Sequence map23-33
PDB IDNA
DrugpediaNA
ReceptorP01589; P14784
DomainNA
Pharmaceutical UseAvailable under the name Proleukin (Chiron). Used in patients with renal cell carcinoma or metastatic melanoma.