| Primary information |
|---|
| ID | 17278 |
| Uniprot ID | Q9NZH8-1 |
| Description | Interleukin-36 gamma (IL-1-related protein 2) (IL-1RP2) (Interleukin-1 epsilon) (IL-1 epsilon) (Interleukin-1 family member 9) (IL-1F9) (Interleukin-1 homolog 1) (IL-1H1) |
| Organism | Homo sapiens |
| Txonomy | Eukaryota; Opisthokonta; Metazoa; Eumetazoa; Bilateria; Deuterostomia; Chordata; Craniata; Vertebrata; Gnathostomata (jawed vertebrates); Teleostomi; Euteleostomi; Sarcopterygii; Dipnotetrapodomorpha; Tetrapoda; Amniota; Mammalia; Theria; Eutheria; Boreoeutheria; Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini; Hominoidea (apes); Hominidae (great apes); Homininae; Homo; Homo sapiens (Human) |
| Subcellular Location | Cytoplasm |
| Developmental Stage | NA |
| Similarity | NA |
| Tissue Specificity | Highly expressed in tissues containing epithelial cells- skin; lung; stomach and esophagus. Expressed in bronchial epithelial. In skin is expressed only in keratinocytes but not in fibroblasts; endoth |
| Post Translational Modification | N-terminal truncation leads to a dramatic enhancement of its activity (1000-fold) (PubMed-21965679). Proteolytically cleaved by cathepsin CTSG (PubMed-30804664). |
| Function | Cytokine that binds to and signals through the IL1RL2/IL-36R receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells. Part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response; similar to the IL-1 system with which it shares the coreceptor IL1RAP. Seems to be involved in skin inflammatory response by acting on keratinocytes; dendritic cells and indirectly on T-cells to drive tissue infiltration; cell maturation and cell proliferation. In cultured keratinocytes induces the expression of macrophage; T-cell; and neutrophil chemokines; such as CCL3; CCL4; CCL5; CCL2; CCL17; CCL22; CL20; CCL5; CCL2; CCL17; CCL22; CXCL8; CCL20 and CXCL1; also stimulates its own expression and that of the prototypic cutaneous pro-inflammatory parameters TNF-alpha; S100A7/psoriasin and inducible NOS. May play a role in pro-inflammatory responses during particular neutrophilic airway inflammation- activ |
| Length | 169 |
| Molecular Weight | 18721 |
| Name | Interleukin-36 gamma |
| Sequence | MCKPITGTINDLNQQVWTLQGQNLVAVPRSDSVTPVTVAVITCKYPEALEQGRGDPIYLGIQNPEMCLYCEKVGEQPTLQLKEQKIMDLYGQPEPVKPFLFYRAKTGRTSTLESVAFPDWFIASSKRDQPIILTSELGKSYNTAFELNIND |
| Sequence map | 20-49 |
| PDB ID | NA |
| Drugpedia | NA |
| Receptor | Q9HB29 |
| Domain | NA |
| Pharmaceutical Use | NA
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