| Primary information |
|---|
| ID | 17275 |
| Uniprot ID | Q14116 |
| Description | Interleukin-18 (IL-18) (Iboctadekin) (Interferon gamma-inducing factor) (IFN-gamma-inducing factor) (Interleukin-1 gamma) (IL-1 gamma) |
| Organism | Homo sapiens |
| Txonomy | Eukaryota; Opisthokonta; Metazoa; Eumetazoa; Bilateria; Deuterostomia; Chordata; Craniata; Vertebrata; Gnathostomata (jawed vertebrates); Teleostomi; Euteleostomi; Sarcopterygii; Dipnotetrapodomorpha; Tetrapoda; Amniota; Mammalia; Theria; Eutheria; Boreoeutheria; Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini; Hominoidea (apes); Hominidae (great apes); Homininae; Homo; Homo sapiens (Human) |
| Subcellular Location | Cytoplasm |
| Developmental Stage | NA |
| Similarity | NA |
| Tissue Specificity | NA |
| Post Translational Modification | The pro-IL-18 precursor is processed by CASP1 or CASP4 to yield the active form. |
| Function | Pro-inflammatory cytokine primarily involved in epithelial barrier repair; polarized T-helper 1 (Th1) cell and natural killer (NK) cell immune responses |
| Length | 193 |
| Molecular Weight | 22326 |
| Name | Interleukin-18 |
| Sequence | FGKLESKLSVIRNLNDQVLFIDQGNRPLFEDMTDSDCRDNAPRTIFIISMYKDSQPRGMAVTISVKCEKISTLSCENKIISFKEMNPPDNIKDTKSDIIFFQRSVPGHDNKMQFESSSYEGYFLACEKERDLFKLILKKEDELGDRSIMFTVQNED |
| Sequence map | 40-13 |
| PDB ID | NA |
| Drugpedia | NA |
| Receptor | Q13478; O95256 |
| Domain | NA |
| Pharmaceutical Use | NA
|