| Primary information |
|---|
| ID | 17266 |
| Uniprot ID | P01584 |
| Description | Interleukin-1 beta (IL-1 beta) (Catabolin) |
| Organism | Homo sapiens |
| Txonomy | Eukaryota; Opisthokonta; Metazoa; Eumetazoa; Bilateria; Deuterostomia; Chordata; Craniata; Vertebrata; Gnathostomata (jawed vertebrates); Teleostomi; Euteleostomi; Sarcopterygii; Dipnotetrapodomorpha; Tetrapoda; Amniota; Mammalia; Theria; Eutheria; Boreoeutheria; Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini; Hominoidea (apes); Hominidae (great apes); Homininae; Homo; Homo sapiens (Human) |
| Subcellular Location | Cytoplasm; cytosol |
| Developmental Stage | NA |
| Similarity | NA |
| Tissue Specificity | Expressed in activated monocytes/macrophages |
| Post Translational Modification | Activation of the IL1B precursor involves a CASP1-catalyzed proteolytic cleavage. Processing and secretion are temporarily associated. |
| Function | Potent pro-inflammatory cytokine |
| Length | 269 |
| Molecular Weight | 30748 |
| Name | Interleukin-1 beta |
| Sequence | PVRSLNCTLRDSQQKSLVMSGPYELKALHLQGQDMEQQVVFSMSFVQGEESNDKIPVALGLKEKNLYLSCVLKDDKPTLQLESVDPKNYPKKKMEKRFVFNKIEINNKLEFESAQFPNWYISTSQAENMPVFLGGTKGGQDITDFTMQFVSS |
| Sequence map | 121-29 |
| PDB ID | NA |
| Drugpedia | NA |
| Receptor | P14778; P27930 |
| Domain | NA |
| Pharmaceutical Use | NA
|