| Primary information |
|---|
| ID | 17265 |
| Uniprot ID | P01583 |
| Description | Interleukin-1 alpha (IL-1 alpha) (Hematopoietin-1) |
| Organism | Homo sapiens |
| Txonomy | Eukaryota; Opisthokonta; Metazoa; Eumetazoa; Bilateria; Deuterostomia; Chordata; Craniata; Vertebrata; Gnathostomata (jawed vertebrates); Teleostomi; Euteleostomi; Sarcopterygii; Dipnotetrapodomorpha; Tetrapoda; Amniota; Mammalia; Theria; Eutheria; Boreoeutheria; Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini; Hominoidea (apes); Hominidae (great apes); Homininae; Homo; Homo sapiens (Human) |
| Subcellular Location | Nucleus |
| Developmental Stage | NA |
| Similarity | NA |
| Tissue Specificity | NA |
| Post Translational Modification | Acetylated within its nuclear localization sequence; which impacts subcellular localization. |
| Function | Cytokine constitutively present intracellularly in nearly all resting non-hematopoietic cells that plays an important role in inflammation and bridges the innate and adaptive immune systems |
| Length | 271 |
| Molecular Weight | 30607 |
| Name | Interleukin-1 alpha |
| Sequence | APFSFLSNVKYNFMRIIKYEFILNDALNQSIIRANDQYLTAAALHNLDEAVKFDMGAYKSSKDDAKITVILRISKTQLYVTAQDEDQPVLLKEMPEIPKTITGSETNLLFFWETHGTKNYFTSVAHPNLFIATKQDYWVCLAGGPPSITDFQILENQA |
| Sequence map | 117-31 |
| PDB ID | NA |
| Drugpedia | NA |
| Receptor | P14778; P27930 |
| Domain | The similarity among the IL-1 precursors suggests |
| Pharmaceutical Use | NA
|