| Primary information |
|---|
| ID | 17249 |
| Uniprot ID | O60565 |
| Description | Gremlin-1 (Cell proliferation-inducing gene 2 protein) (Cysteine knot superfamily 1; BMP antagonist 1) (DAN domain family member 2) (Down-regulated in Mos-transformed cells protein) (Increased in high glucose protein 2) (IHG-2) |
| Organism | Homo sapiens |
| Txonomy | Eukaryota; Opisthokonta; Metazoa; Eumetazoa; Bilateria; Deuterostomia; Chordata; Craniata; Vertebrata; Gnathostomata (jawed vertebrates); Teleostomi; Euteleostomi; Sarcopterygii; Dipnotetrapodomorpha; Tetrapoda; Amniota; Mammalia; Theria; Eutheria; Boreoeutheria; Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini; Hominoidea (apes); Hominidae (great apes); Homininae; Homo; Homo sapiens (Human) |
| Subcellular Location | Secreted |
| Developmental Stage | NA |
| Similarity | NA |
| Tissue Specificity | Highly expressed in small intestine; fetal brain and colon. Expression is restricted to intestinal subepithelial myofibroblasts |
| Post Translational Modification | NA |
| Function | Cytokine that may play an important role during carcinogenesis and metanephric kidney organogenesis; as a BMP antagonist required for early limb outgrowth and patterning in maintaining the FGF4-SHH feedback loop. Down-regulates the BMP4 signaling in a dose-dependent manner. Antagonist of BMP2; inhibits BMP2-mediated differentiation of osteoblasts (in vitro) |
| Length | 184 |
| Molecular Weight | 20697 |
| Name | Gremlin-1 |
| Sequence | KKGSQGAIPPPDKAQHNDSEQTQSPQQPGSRNRGRGQGRGTAMPGEEVLESSQEALHVTERKYLKRDWCKTQPLKQTIHEEGCNSRTIINRFCYGQCNSFYIPRHIRKEEGSFQSCSFCKPKKFTTMMVTLNCPELQPPTKKKRVTRVKQCRCISIDLD |
| Sequence map | 28-04 |
| PDB ID | NA |
| Drugpedia | NA |
| Receptor | P35968 |
| Domain | NA |
| Pharmaceutical Use | NA
|