| Primary information |
|---|
| ID | 17246 |
| Uniprot ID | P04141 |
| Description | Granulocyte-macrophage colony-stimulating factor (GM-CSF) (Colony-stimulating factor) (CSF) (Molgramostin) (Sargramostim) |
| Organism | Homo sapiens |
| Txonomy | Eukaryota; Opisthokonta; Metazoa; Eumetazoa; Bilateria; Deuterostomia; Chordata; Craniata; Vertebrata; Gnathostomata (jawed vertebrates); Teleostomi; Euteleostomi; Sarcopterygii; Dipnotetrapodomorpha; Tetrapoda; Amniota; Mammalia; Theria; Eutheria; Boreoeutheria; Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini; Hominoidea (apes); Hominidae (great apes); Homininae; Homo; Homo sapiens (Human) |
| Subcellular Location | Secreted |
| Developmental Stage | NA |
| Similarity | NA |
| Tissue Specificity | NA |
| Post Translational Modification | NA |
| Function | Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages; including granulocytes; macrophages; eosinophils and erythrocytes. |
| Length | 144 |
| Molecular Weight | 16295 |
| Name | Granulocyte-macrophage colony-stimulating factor |
| Sequence | PARSPSPSTQPWEHVNAIQEARRLLNLSRDTAAEMNETVEVISEMFDLQEPTCLQTRLELYKQGLRGSLTKLKGPLTMMASHYKQHCPPTPETSCATQIITFESFKENLKDFLLVIPFDCWEPVQE |
| Sequence map | 20-24 |
| PDB ID | NA |
| Drugpedia | NA |
| Receptor | P32927; P15509 |
| Domain | NA |
| Pharmaceutical Use | Available under the names Leukine (Immunex) and Leucomax (Novartis). Used in myeloid reconstitution following bone marrow transplant; bone marrow transplant engraftment failure or delay; mobilization |