| Primary information |
|---|
| ID | 17243 |
| Uniprot ID | O14793 |
| Description | Growth/differentiation factor 8 (GDF-8) (Myostatin) |
| Organism | Homo sapiens |
| Txonomy | Eukaryota; Opisthokonta; Metazoa; Eumetazoa; Bilateria; Deuterostomia; Chordata; Craniata; Vertebrata; Gnathostomata (jawed vertebrates); Teleostomi; Euteleostomi; Sarcopterygii; Dipnotetrapodomorpha; Tetrapoda; Amniota; Mammalia; Theria; Eutheria; Boreoeutheria; Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini; Hominoidea (apes); Hominidae (great apes); Homininae; Homo; Homo sapiens (Human) |
| Subcellular Location | Secreted |
| Developmental Stage | NA |
| Similarity | NA |
| Tissue Specificity | NA |
| Post Translational Modification | Synthesized as large precursor molecule that undergoes proteolytic cleavage to generate an N-terminal propeptide and a disulfide linked C-terminal dimer; which is the biologically active molecule. The |
| Function | Acts specifically as a negative regulator of skeletal muscle growth. |
| Length | 375 |
| Molecular Weight | 42750 |
| Name | Growth/differentiation factor 8 |
| Sequence | FGLDCDEHSTESRCCRYPLTVDFEAFGWDWIIAPKRYKANYCSGECEFVFLQKYPHTHLVHQANPRGSAGPCCTPTKMSPINMLYFNGKEQIIYGKIPAMVVDRCGCS |
| Sequence map | 273-15 |
| PDB ID | NA |
| Drugpedia | NA |
| Receptor | Q13705 |
| Domain | NA |
| Pharmaceutical Use | NA
|