| Primary information |
|---|
| ID | 17232 |
| Uniprot ID | P09382 |
| Description | Galectin-1 (Gal-1) (14 kDa laminin-binding protein) (HLBP14) (14 kDa lectin) (Beta-galactoside-binding lectin L-14-I) (Galaptin) (HBL) (HPL) (Lactose-binding lectin 1) (Lectin galactoside-binding soluble 1) (Putative MAPK-activating protein PM12) (S-Lac lectin 1) |
| Organism | Homo sapiens |
| Txonomy | Eukaryota; Opisthokonta; Metazoa; Eumetazoa; Bilateria; Deuterostomia; Chordata; Craniata; Vertebrata; Gnathostomata (jawed vertebrates); Teleostomi; Euteleostomi; Sarcopterygii; Dipnotetrapodomorpha; Tetrapoda; Amniota; Mammalia; Theria; Eutheria; Boreoeutheria; Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini; Hominoidea (apes); Hominidae (great apes); Homininae; Homo; Homo sapiens (Human) |
| Subcellular Location | Secreted; extracellular space; extracellular matrix |
| Developmental Stage | NA |
| Similarity | NA |
| Tissue Specificity | Expressed in placenta; maternal decidua and fetal membranes. Within placenta; expressed in trophoblasts; stromal cells; villous endothelium; syncytiotrophoblast apical membrane and villous stroma. Wit |
| Post Translational Modification | NA |
| Function | Lectin that binds beta-galactoside and a wide array of complex carbohydrates. Plays a role in regulating apoptosis; cell proliferation and cell differentiation. Inhibits CD45 protein phosphatase activity and therefore the dephosphorylation of Lyn kinase. Strong inducer of T-cell apoptosis. |
| Length | 135 |
| Molecular Weight | 14716 |
| Name | Galectin-1 |
| Sequence | CGLVASNLNLKPGECLRVRGEVAPDAKSFVLNLGKDSNNLCLHFNPRFNAHGDANTIVCNSKDGGAWGTEQREAVFPFQPGSVAEVCITFDQANLTVKLPDGYEFKFPNRLNLEAINYMAADGDFKIKCVAFD |
| Sequence map | 4-15 |
| PDB ID | NA |
| Drugpedia | NA |
| Receptor | Q16581; Q8WXI7; P06729; P01730; P08575; P06731; P09564; Q08380; NA |
| Domain | NA |
| Pharmaceutical Use | NA
|