| Primary information |
|---|
| ID | 17216 |
| Uniprot ID | P61328 |
| Description | Fibroblast growth factor 12 (FGF-12) (Fibroblast growth factor homologous factor 1) (FHF-1) (Myocyte-activating factor) |
| Organism | Homo sapiens |
| Txonomy | Eukaryota; Opisthokonta; Metazoa; Eumetazoa; Bilateria; Deuterostomia; Chordata; Craniata; Vertebrata; Gnathostomata (jawed vertebrates); Teleostomi; Euteleostomi; Sarcopterygii; Dipnotetrapodomorpha; Tetrapoda; Amniota; Mammalia; Theria; Eutheria; Boreoeutheria; Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini; Hominoidea (apes); Hominidae (great apes); Homininae; Homo; Homo sapiens (Human) |
| Subcellular Location | Nucleus |
| Developmental Stage | NA |
| Similarity | NA |
| Tissue Specificity | Brain; eye and testis; highly expressed in embryonic retina; olfactory epithelium; olfactory bulb; and in a segmental pattern of the body wall; in adult olfactory bulb; less in cerebellum; deep cerebe |
| Post Translational Modification | NA |
| Function | Involved in nervous system development and function. Involved in the positive regulation of voltage-gated sodium channel activity. Promotes neuronal excitability by elevating the voltage dependence of neuronal sodium channel SCN8A fast inactivation. |
| Length | 243 |
| Molecular Weight | 27399 |
| Name | Fibroblast growth factor 12 |
| Sequence | AAAIASSLIRQKRQARESNSDRVSASKRRSSPSKDGRSLCERHVLGVFSKVRFCSGRKRPVRRRPEPQLKGIVTRLFSQQGYFLQMHPDGTIDGTKDENSDYTLFNLIPVGLRVVAIQGVKASLYVAMNGEGYLYSSDVFTPECKFKESVFENYYVIYSSTLYRQQESGRAWFLGLNKEGQIMKGNRVKKTKPSSHFVPKPIEVCMYREPSLHEIGEKQGRSRKSSGTPTMNGGKVVNQDST |
| Sequence map | 05-03 |
| PDB ID | NA |
| Drugpedia | NA |
| Receptor | Q9UI33 |
| Domain | NA |
| Pharmaceutical Use | NA
|