| Primary information |
|---|
| ID | 17201 |
| Uniprot ID | O43323 |
| Description | Desert hedgehog protein (DHH) (EC 3.1.-.-) (HHG-3) [Cleaved into- Desert hedgehog protein N-product (DHH-N)] |
| Organism | Homo sapiens |
| Txonomy | Eukaryota; Opisthokonta; Metazoa; Eumetazoa; Bilateria; Deuterostomia; Chordata; Craniata; Vertebrata; Gnathostomata (jawed vertebrates); Teleostomi; Euteleostomi; Sarcopterygii; Dipnotetrapodomorpha; Tetrapoda; Amniota; Mammalia; Theria; Eutheria; Boreoeutheria; Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini; Hominoidea (apes); Hominidae (great apes); Homininae; Homo; Homo sapiens (Human) |
| Subcellular Location | [Desert hedgehog protein N-product]- Cell membrane |
| Developmental Stage | NA |
| Similarity | NA |
| Tissue Specificity | NA |
| Post Translational Modification | [Desert hedgehog protein]- Partially autoproteolyzed (PubMed-30298535; PubMed-24342078). The C-terminal domain displays an autoproteolysis activity and a cholesterol transferase activity. Both activit |
| Function | [Desert hedgehog protein]- The C-terminal part of the desert hedgehog protein precursor displays an autoproteolysis and a cholesterol transferase activity. Both activities result in the cleavage of the full-length protein into two parts (N-product and C-product) followed by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated N-product. Both activities occur in the reticulum endoplasmic. Functions in cell-cell mediated juxtacrine signaling |
| Length | 396 |
| Molecular Weight | 43577 |
| Name | Desert hedgehog protein |
| Sequence | GPGRGPVGRRRYARKQLVPLLYKQFVPGVPERTLGASGPAEGRVARGSERFRDLVPNYNPDIIFKDEENSGADRLMTERCKERVNALAIAVMNMWPGVRLRVTEGWDEDGHHAQDSLHYEGRALDITTSDRDRNKYGLLARLAVEAGFDWVYYESRNHVHVSVKADNSLAVRAGGCFPGNATVRLWSGERKGLRELHRGDWVLAADASGRVVPTPVLLFLDRDLQRRASFVAVETEWPPRKLLLTPWHLVFAARGPAPAPGDFAPVFARRLRAGDSVLAPGGDALRPARVARVAREEAVGVFAPLTAHGTLLVNDVLASCYAVLESHQWAHRAFAPLRLLHALGALLPGGAVQPTGMHWYSRLLYRLAEELLG |
| Sequence map | 29-36 |
| PDB ID | NA |
| Drugpedia | NA |
| Receptor | Q13635 |
| Domain | [Desert hedgehog protein N-product]: Binds calcium |
| Pharmaceutical Use | NA
|