| Primary information |
|---|
| ID | 17200 |
| Uniprot ID | Q9H2A7 |
| Description | C-X-C motif chemokine 16 (Scavenger receptor for phosphatidylserine and oxidized low density lipoprotein) (SR-PSOX) (Small-inducible cytokine B16) (Transmembrane chemokine CXCL16) |
| Organism | Homo sapiens |
| Txonomy | Eukaryota; Opisthokonta; Metazoa; Eumetazoa; Bilateria; Deuterostomia; Chordata; Craniata; Vertebrata; Gnathostomata (jawed vertebrates); Teleostomi; Euteleostomi; Sarcopterygii; Dipnotetrapodomorpha; Tetrapoda; Amniota; Mammalia; Theria; Eutheria; Boreoeutheria; Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini; Hominoidea (apes); Hominidae (great apes); Homininae; Homo; Homo sapiens (Human) |
| Subcellular Location | Cell membrane |
| Developmental Stage | NA |
| Similarity | NA |
| Tissue Specificity | Expressed in T-cell areas. Expressed in spleen; lymph nodes; lung; kidney; small intestine and thymus. Weak expression in heart and liver and no expression in brain and bone marrow. |
| Post Translational Modification | Glycosylated. |
| Function | Acts as a scavenger receptor on macrophages; which specifically binds to OxLDL (oxidized low density lipoprotein); suggesting that it may be involved in pathophysiology such as atherogenesis. Induces a strong chemotactic response. Induces calcium mobilization. Binds to CXCR6/Bonzo. |
| Length | 254 |
| Molecular Weight | 27579 |
| Name | C-X-C motif chemokine 16 |
| Sequence | EGSVTGSCYCGKRISSDSPPSVQFMNRLRKHLRAYHRCLYYTRFQLLSWSVCGGNKDPWVQELMSCLDLKECGHAYSGIVAHQKHLLPTSPPISQASEGASSDIHTPAQMLLSTLQSTQRPTLPVGSLSSDKELTRPNETTIHTAGHSLAAGPEAGENQKQPEKNAGPTARTSATVPVLCLLAIIFILTAALSYVLCKRRRGQSPQSSPDLPVHYIPVAPDSNT |
| Sequence map | 34-14 |
| PDB ID | NA |
| Drugpedia | NA |
| Receptor | O00574 |
| Domain | NA |
| Pharmaceutical Use | NA
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