| Primary information |
|---|
| ID | 17191 |
| Uniprot ID | P29965 |
| Description | CD40 ligand (CD40-L) (T-cell antigen Gp39) (TNF-related activation protein) (TRAP) (Tumor necrosis factor ligand superfamily member 5) (CD antigen CD154) [Cleaved into- CD40 ligand; membrane form; CD40 ligand; soluble form (sCD40L)] |
| Organism | Homo sapiens |
| Txonomy | Eukaryota; Opisthokonta; Metazoa; Eumetazoa; Bilateria; Deuterostomia; Chordata; Craniata; Vertebrata; Gnathostomata (jawed vertebrates); Teleostomi; Euteleostomi; Sarcopterygii; Dipnotetrapodomorpha; Tetrapoda; Amniota; Mammalia; Theria; Eutheria; Boreoeutheria; Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini; Hominoidea (apes); Hominidae (great apes); Homininae; Homo; Homo sapiens (Human) |
| Subcellular Location | Cell membrane |
| Developmental Stage | NA |
| Similarity | NA |
| Tissue Specificity | Specifically expressed on activated CD4+ T-lymphocytes. |
| Post Translational Modification | The soluble form derives from the membrane form by proteolytic processing. |
| Function | Cytokine that acts as a ligand to CD40/TNFRSF5 |
| Length | 261 |
| Molecular Weight | 29274 |
| Name | CD40 ligand; membrane form |
| Sequence | IETYNQTSPRSAATGLPISMKIFMYLLTVFLITQMIGSALFAVYLHRRLDKIEDERNLHEDFVFMKTIQRCNTGERSLSLLNCEEIKSQFEGFVKDIMLNKEETKKENSFEMQKGDQNPQIAAHVISEASSKTTSVLQWAEKGYYTMSNNLVTLENGKQLTVKRQGLYYIYAQVTFCSNREASSQAPFIASLCLKSPGRFERILLRAANTHSSAKPCGQQSIHLGGVFELQPGASVFVNVTDPSQVSHGTGFTSFGLLKL |
| Sequence map | 5-21 |
| PDB ID | NA |
| Drugpedia | NA |
| Receptor | P25942; P78324 |
| Domain | NA |
| Pharmaceutical Use | NA
|