| Primary information |
|---|
| ID | 17185 |
| Uniprot ID | Q16619 |
| Description | Cardiotrophin-1 (CT-1) |
| Organism | Homo sapiens |
| Txonomy | Eukaryota; Opisthokonta; Metazoa; Eumetazoa; Bilateria; Deuterostomia; Chordata; Craniata; Vertebrata; Gnathostomata (jawed vertebrates); Teleostomi; Euteleostomi; Sarcopterygii; Dipnotetrapodomorpha; Tetrapoda; Amniota; Mammalia; Theria; Eutheria; Boreoeutheria; Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini; Hominoidea (apes); Hominidae (great apes); Homininae; Homo; Homo sapiens (Human) |
| Subcellular Location | Secreted |
| Developmental Stage | NA |
| Similarity | NA |
| Tissue Specificity | Highly expressed in heart; skeletal muscle; prostate and ovary. Lower levels in lung; kidney; pancreas; thymus; testis and small intestine. Little or no expression in brain; placenta; liver; spleen; c |
| Post Translational Modification | NA |
| Function | Induces cardiac myocyte hypertrophy in vitro. Binds to and activates the ILST/gp130 receptor. |
| Length | 201 |
| Molecular Weight | 21227 |
| Name | Cardiotrophin-1 |
| Sequence | SRREGSLEDPQTDSSVSLLPHLEAKIRQTHSLAHLLTKYAEQLLQEYVQLQGDPFGLPSFSPPRLPVAGLSAPAPSHAGLPVHERLRLDAAALAALPPLLDAVCRRQAELNPRAPRLLRRLEDAARQARALGAAVEALLAALGAANRGPRAEPPAATASAASATGVFPAKVLGLRVCGLYREWLSRTEGDLGQLLPGGSA |
| Sequence map | 4-21 |
| PDB ID | NA |
| Drugpedia | NA |
| Receptor | P40189 |
| Domain | NA |
| Pharmaceutical Use | NA
|