| Primary information |
|---|
| ID | 17183 |
| Uniprot ID | P23560 |
| Description | Brain-derived neurotrophic factor (BDNF) (Abrineurin) [Cleaved into- BDNF precursor form (ProBDNF)] |
| Organism | Homo sapiens |
| Txonomy | Eukaryota; Opisthokonta; Metazoa; Eumetazoa; Bilateria; Deuterostomia; Chordata; Craniata; Vertebrata; Gnathostomata (jawed vertebrates); Teleostomi; Euteleostomi; Sarcopterygii; Dipnotetrapodomorpha; Tetrapoda; Amniota; Mammalia; Theria; Eutheria; Boreoeutheria; Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini; Hominoidea (apes); Hominidae (great apes); Homininae; Homo; Homo sapiens (Human) |
| Subcellular Location | Secreted |
| Developmental Stage | NA |
| Similarity | NA |
| Tissue Specificity | Detected in blood plasma and in saliva |
| Post Translational Modification | [BDNF precursor form]- N-glycosylated and glycosulfated; contrary to mature BDNF. |
| Function | Important signaling molecule that activates signaling cascades downstream of NTRK2 |
| Length | 247 |
| Molecular Weight | 27818 |
| Name | BDNF precursor form |
| Sequence | PMKEANIRGQGGLAYPGVRTHGTLESVNGPKAGSRGLTSLADTFEHVIEELLDEDQKVRPNEENNKDADLYTSRVMLSSQVPLEPPLLFLLEEYKNYLDAANMSMRVRRHSDPARRGELSVCDSISEWVTAADKKTAVDMSGGTVTVLEKVPVSKGQLKQYFYETKCNPMGYTKEGCRGIDKRHWNSQCRTTQSYVRALTMDSKKRIGWRFIRIDTSCVCTLTIKRGR |
| Sequence map | 23-07 |
| PDB ID | NA |
| Drugpedia | NA |
| Receptor | P08138; Q16620 |
| Domain | NA |
| Pharmaceutical Use | NA
|