Detailed description page of Hmrbase2

This page displays user query in tabular form.

17180 details
Primary information
ID17180
Uniprot IDO95390
DescriptionGrowth/differentiation factor 11 (GDF-11) (Bone morphogenetic protein 11) (BMP-11)
OrganismHomo sapiens
TxonomyEukaryota; Opisthokonta; Metazoa; Eumetazoa; Bilateria; Deuterostomia; Chordata; Craniata; Vertebrata; Gnathostomata (jawed vertebrates); Teleostomi; Euteleostomi; Sarcopterygii; Dipnotetrapodomorpha; Tetrapoda; Amniota; Mammalia; Theria; Eutheria; Boreoeutheria; Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini; Hominoidea (apes); Hominidae (great apes); Homininae; Homo; Homo sapiens (Human)
Subcellular LocationSecreted
Developmental StageNA
SimilarityNA
Tissue SpecificityIn the embryo; strong expression is seen in the palatal epithelia; including the medial edge epithelial and midline epithelial seam of the palatal shelves. Less pronounced expression is also seen thro
Post Translational ModificationSynthesized as large precursor molecule that undergoes proteolytic cleavage by furin-like proteases (PubMed-31215115). This produces an inactive form consisting of the mature C-terminal portion non-co
FunctionSecreted signal that acts globally to regulate anterior/posterior axial patterning during development. May play critical roles in patterning both mesodermal and neural tissues. It is required for proper vertebral patterning and orofacial development
Length407
Molecular Weight45091
NameGrowth/differentiation factor 11
SequenceLGLDCDEHSSESRCCRYPLTVDFEAFGWDWIIAPKRYKANYCSGQCEYMFMQKYPHTHLVQQANPRGSAGPCCTPTKMSPINMLYFNDKQQIIYGKIPGMVVDRCGCS
Sequence map305-47
PDB IDNA
DrugpediaNA
ReceptorP27037
DomainNA
Pharmaceutical UseNA