| Primary information |
|---|
| ID | 17178 |
| Uniprot ID | P81534 |
| Description | Beta-defensin 103 (Beta-defensin 3) (BD-3) (DEFB-3) (HBD3) (hBD-3) (Defensin; beta 103) (Defensin-like protein) |
| Organism | Homo sapiens |
| Txonomy | Eukaryota; Opisthokonta; Metazoa; Eumetazoa; Bilateria; Deuterostomia; Chordata; Craniata; Vertebrata; Gnathostomata (jawed vertebrates); Teleostomi; Euteleostomi; Sarcopterygii; Dipnotetrapodomorpha; Tetrapoda; Amniota; Mammalia; Theria; Eutheria; Boreoeutheria; Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini; Hominoidea (apes); Hominidae (great apes); Homininae; Homo; Homo sapiens (Human) |
| Subcellular Location | Secreted |
| Developmental Stage | NA |
| Similarity | NA |
| Tissue Specificity | Highly expressed in skin and tonsils; and to a lesser extent in trachea; uterus; kidney; thymus; adenoid; pharynx and tongue. Low expression in salivary gland; bone marrow; colon; stomach; polyp and l |
| Post Translational Modification | NA |
| Function | Exhibits antimicrobial activity against Gram-positive bacteria S.aureus and S.pyogenes; Gram-negative bacteria P.aeruginosa and E.coli and the yeast C.albicans. Kills multiresistant S.aureus and vancomycin-resistant E.faecium. No significant hemolytic activity was observed. |
| Length | 67 |
| Molecular Weight | 7697 |
| Name | NA |
| Sequence | NA |
| Sequence map | NA |
| PDB ID | NA |
| Drugpedia | NA |
| Receptor | Q15399; O60603 |
| Domain | NA |
| Pharmaceutical Use | NA
|