| Primary information |
|---|
| ID | 17170 |
| Uniprot ID | P02649 |
| Description | Apolipoprotein E (Apo-E) |
| Organism | Homo sapiens |
| Txonomy | Eukaryota; Opisthokonta; Metazoa; Eumetazoa; Bilateria; Deuterostomia; Chordata; Craniata; Vertebrata; Gnathostomata (jawed vertebrates); Teleostomi; Euteleostomi; Sarcopterygii; Dipnotetrapodomorpha; Tetrapoda; Amniota; Mammalia; Theria; Eutheria; Boreoeutheria; Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini; Hominoidea (apes); Hominidae (great apes); Homininae; Homo; Homo sapiens (Human) |
| Subcellular Location | Secreted |
| Developmental Stage | NA |
| Similarity | NA |
| Tissue Specificity | Produced by several tissues and cell types and mainly found associated with lipid particles in the plasma; the interstitial fluid and lymph |
| Post Translational Modification | APOE exists as multiple glycosylated and sialylated glycoforms within cells and in plasma (PubMed-29516132). The extent of glycosylation and sialylation are tissue and context specific (PubMed-2951613 |
| Function | APOE is an apolipoprotein; a protein associating with lipid particles; that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids |
| Length | 317 |
| Molecular Weight | 36154 |
| Name | Apolipoprotein E |
| Sequence | VEQAVETEPEPELRQQTEWQSGQRWELALGRFWDYLRWVQTLSEQVQEELLSSQVTQELRALMDETMKELKAYKSELEEQLTPVAEETRARLSKELQAAQARLGADMEDVCGRLVQYRGEVQAMLGQSTEELRVRLASHLRKLRKRLLRDADDLQKRLAVYQAGAREGAERGLSAIRERLGPLVEQGRVRAATVGSLAGQPLQERAQAWGERLRARMEEMGSRTRDRLDEVKEQVAEVRAKLEEQAQQIRLQAEAFQARLKSWFEPLVEDMQRQWAGLVEKVQAAVGTSAAPVPSDNH |
| Sequence map | 24-17 |
| PDB ID | NA |
| Drugpedia | NA |
| Receptor | P01130; Q07954; Q8WTV0 |
| Domain | NA |
| Pharmaceutical Use | NA
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