| Primary information |
|---|
| ID | 17163 |
| Uniprot ID | P02763 |
| Description | Alpha-1-acid glycoprotein 1 (AGP 1) (Orosomucoid-1) (OMD 1) |
| Organism | Homo sapiens |
| Txonomy | Eukaryota; Opisthokonta; Metazoa; Eumetazoa; Bilateria; Deuterostomia; Chordata; Craniata; Vertebrata; Gnathostomata (jawed vertebrates); Teleostomi; Euteleostomi; Sarcopterygii; Dipnotetrapodomorpha; Tetrapoda; Amniota; Mammalia; Theria; Eutheria; Boreoeutheria; Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini; Hominoidea (apes); Hominidae (great apes); Homininae; Homo; Homo sapiens (Human) |
| Subcellular Location | Secreted |
| Developmental Stage | NA |
| Similarity | NA |
| Tissue Specificity | Expressed by the liver and secreted in plasma. |
| Post Translational Modification | N-glycosylated. N-glycan heterogeneity at Asn-33- Hex5HexNAc4 (minor); Hex6HexNAc5 (major) and dHex1Hex6HexNAc5 (minor). |
| Function | Functions as transport protein in the blood stream. Binds various ligands in the interior of its beta-barrel domain. Also binds synthetic drugs and influences their distribution and availability in the body. Appears to function in modulating the activity of the immune system during the acute-phase reaction. |
| Length | 201 |
| Molecular Weight | 23540 |
| Name | Alpha-1-acid glycoprotein 1 |
| Sequence | IPLCANLVPVPITNATLDRITGKWFYIASAFRNEEYNKSVQEIQATFFYFTPNKTEDTIFLREYQTRQDQCIYNTTYLNVQRENGTISRYVGGQEHFAHLLILRDTKTYMLAFDVNDEKNWGLSVYADKPETTKEQLGEFYEALDCLRIPKSDVVYTDWKKDKCEPLEKQHEKERKQEEGES |
| Sequence map | 22-21 |
| PDB ID | NA |
| Drugpedia | NA |
| Receptor | P51681 |
| Domain | Contains a beta-barrel that binds various ligands |
| Pharmaceutical Use | NA
|