| Primary information |
|---|
| ID | 17156 |
| Uniprot ID | P0DL76 |
| Description | FMRFamide-like neuropeptides 1 [Cleaved into- PNFMRY-amide; AGSDPNFLRF-amide; SQPNFLRF-amide; ASGDPNFLRF-amide; SDPNFLRF-amide (PF1); AAADPNFLRF-amide; SADPNFLRF-amide (PF2); PNFLRF-amide] |
| Organism | Conus tulipa |
| Txonomy | Caenorhabditis ; Peloderinae ; Rhabditidae ; Rhabditoidea ; Rhabditomorpha ; Rhabditina ; Rhabditida ; Chromadorea ; Nematoda ; Ecdysozoa ; Protostomia ; Bilateria ; Eumetazoa ; Metazoa ; Opisthokonta ; Eukaryota ; cellular organisms |
| Subcellular Location | secreted |
| Developmental Stage | NA |
| Similarity | Vasopressin/oxytocin family |
| Tissue Specificity | Each flp gene is expressed in a distinct set of neurons. Flp-1 is expressed in the AVA interneurons; the M5 cholinergic pharyngeal motoneurons; and the AIA; AIY; AVE; AVK; RIG and RMG neurons. |
| Post Translational Modification | T9 Glycine amide |
| Function | Interacts with high affinity with oxytocin receptor (OXTR) (Ki=108 nM) and vasopressin V1a receptor (V1aR/AVPR1A) (Ki=319 nM). Acts as a partial agonist on OXTR (Kact=37 nM; 22% of oxytocin maximum activity at 10 ¦ÌM); and as a full antagonist on V1aR (Kinact=329 nM).Does not show binding with vasopressin V1b and V2 receptors (up to 10 ¦ÌM). Shows a weak agonist activity on V1bR/AVPR1B (9% at 10 ¦ÌM).Position 9 is important residue for antagonist activity on V1aR/AVPR1A (a Gly in this position produces agonist activi |
| Length | 175 |
| Molecular Weight | 19 |
| Name | Conopressin-T |
| Sequence | CYIQNCLRV |
| Sequence map | NA |
| PDB ID | NA |
| Drugpedia | NA |
| Receptor | NA |
| Domain | The cysteine framework is C-C. |
| Pharmaceutical Use | NA
|