Detailed description page of Hmrbase2

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16995 details
Primary information
ID16995
Uniprot IDP0DQH8
DescriptionCalliFMRFamide-8
OrganismConus cancellatus
TxonomyCalliphora ; Calliphorinae ; Calliphoridae ; Oestroidea ; Calyptratae ; Schizophora ; Cyclorrhapha ; Eremoneura ; Muscomorpha ; Brachycera ; Diptera ; Endopterygota (cohort); Neoptera (infraclass); Pterygota (subclass); Dicondylia ; Insecta ; Hexapoda ; Pancrustacea ; Mandibulata ; Arthropoda ; Panarthropoda ; Ecdysozoa ; Protostomia ; Bilateria ; Eumetazoa ; Metazoa ; Opisthokonta ; Eukaryota ; cellular organisms
Subcellular Locationsecreted
Developmental StageNA
SimilarityFMRFamide related peptide family
Tissue SpecificityNA
Post Translational ModificationNA
Functionbe only weakly active on both ASIC channels and nicotinic acetylcholine receptors (nAChRs). Shows a very weak inhibition of peak current of rat ASIC1a and ASIC3 . No inhibition or very weak desensitization of both rat ASIC1a and ASIC3 are observed. Reversibly inhibits both human alpha-7/CHRNA7 nAChRs and human alpha-1-beta-1-delta-epsilon (CHRNA1-CHRNB1-CHRND-CHRNE) nAChRs
Length8
Molecular Weight957
NameConorfamide-As2b
SequenceRIRKPIFAFPRF
Sequence mapNA
PDB IDNA
DrugpediaNA
ReceptorNA
DomainNA
Pharmaceutical UseNA