| Primary information |
|---|
| ID | 16995 |
| Uniprot ID | P0DQH8 |
| Description | CalliFMRFamide-8 |
| Organism | Conus cancellatus |
| Txonomy | Calliphora ; Calliphorinae ; Calliphoridae ; Oestroidea ; Calyptratae ; Schizophora ; Cyclorrhapha ; Eremoneura ; Muscomorpha ; Brachycera ; Diptera ; Endopterygota (cohort); Neoptera (infraclass); Pterygota (subclass); Dicondylia ; Insecta ; Hexapoda ; Pancrustacea ; Mandibulata ; Arthropoda ; Panarthropoda ; Ecdysozoa ; Protostomia ; Bilateria ; Eumetazoa ; Metazoa ; Opisthokonta ; Eukaryota ; cellular organisms |
| Subcellular Location | secreted |
| Developmental Stage | NA |
| Similarity | FMRFamide related peptide family |
| Tissue Specificity | NA |
| Post Translational Modification | NA |
| Function | be only weakly active on both ASIC channels and nicotinic acetylcholine receptors (nAChRs). Shows a very weak inhibition of peak current of rat ASIC1a and ASIC3 . No inhibition or very weak desensitization of both rat ASIC1a and ASIC3 are observed. Reversibly inhibits both human alpha-7/CHRNA7 nAChRs and human alpha-1-beta-1-delta-epsilon (CHRNA1-CHRNB1-CHRND-CHRNE) nAChRs |
| Length | 8 |
| Molecular Weight | 957 |
| Name | Conorfamide-As2b |
| Sequence | RIRKPIFAFPRF |
| Sequence map | NA |
| PDB ID | NA |
| Drugpedia | NA |
| Receptor | NA |
| Domain | NA |
| Pharmaceutical Use | NA
|