Primary information |
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ID | 16994 |
Uniprot ID | P0DQH8 |
Description | CalliFMRFamide-7 |
Organism | Conus cancellatus |
Txonomy | Calliphora ; Calliphorinae ; Calliphoridae ; Oestroidea ; Calyptratae ; Schizophora ; Cyclorrhapha ; Eremoneura ; Muscomorpha ; Brachycera ; Diptera ; Endopterygota (cohort); Neoptera (infraclass); Pterygota (subclass); Dicondylia ; Insecta ; Hexapoda ; Pancrustacea ; Mandibulata ; Arthropoda ; Panarthropoda ; Ecdysozoa ; Protostomia ; Bilateria ; Eumetazoa ; Metazoa ; Opisthokonta ; Eukaryota ; cellular organisms |
Subcellular Location | secreted |
Developmental Stage | NA |
Similarity | FMRFamide related peptide family |
Tissue Specificity | NA |
Post Translational Modification | T12 Phenylalanine amide |
Function | Be active on both ASIC channels and nicotinic acetylcholine receptors (nAChRs). Potentiates ASIC1a. Inhibits desensitization of ASIC1a and to a lesser degree ASIC3 currents; resulting in a sustained opening of channels in the presence of low pH . Inhibits with a slow reversibility human alpha-7/CHRNA7 nAChRs and with a rapid reversibility human alpha-1-beta-1-delta-epsilon (CHRNA1-CHRNB1-CHRND-CHRNE) nAChRs |
Length | 9 |
Molecular Weight | 1 |
Name | Conorfamide-As2a |
Sequence | RIRKPIFAFPRF |
Sequence map | NA |
PDB ID | NA |
Drugpedia | NA |
Receptor | NA |
Domain | NA |
Pharmaceutical Use | NA
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