| Primary information |
|---|
| ID | 16994 |
| Uniprot ID | P0DQH8 |
| Description | CalliFMRFamide-7 |
| Organism | Conus cancellatus |
| Txonomy | Calliphora ; Calliphorinae ; Calliphoridae ; Oestroidea ; Calyptratae ; Schizophora ; Cyclorrhapha ; Eremoneura ; Muscomorpha ; Brachycera ; Diptera ; Endopterygota (cohort); Neoptera (infraclass); Pterygota (subclass); Dicondylia ; Insecta ; Hexapoda ; Pancrustacea ; Mandibulata ; Arthropoda ; Panarthropoda ; Ecdysozoa ; Protostomia ; Bilateria ; Eumetazoa ; Metazoa ; Opisthokonta ; Eukaryota ; cellular organisms |
| Subcellular Location | secreted |
| Developmental Stage | NA |
| Similarity | FMRFamide related peptide family |
| Tissue Specificity | NA |
| Post Translational Modification | T12 Phenylalanine amide |
| Function | Be active on both ASIC channels and nicotinic acetylcholine receptors (nAChRs). Potentiates ASIC1a. Inhibits desensitization of ASIC1a and to a lesser degree ASIC3 currents; resulting in a sustained opening of channels in the presence of low pH . Inhibits with a slow reversibility human alpha-7/CHRNA7 nAChRs and with a rapid reversibility human alpha-1-beta-1-delta-epsilon (CHRNA1-CHRNB1-CHRND-CHRNE) nAChRs |
| Length | 9 |
| Molecular Weight | 1 |
| Name | Conorfamide-As2a |
| Sequence | RIRKPIFAFPRF |
| Sequence map | NA |
| PDB ID | NA |
| Drugpedia | NA |
| Receptor | NA |
| Domain | NA |
| Pharmaceutical Use | NA
|