Detailed description page of Hmrbase2

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16994 details
Primary information
ID16994
Uniprot IDP0DQH8
DescriptionCalliFMRFamide-7
OrganismConus cancellatus
TxonomyCalliphora ; Calliphorinae ; Calliphoridae ; Oestroidea ; Calyptratae ; Schizophora ; Cyclorrhapha ; Eremoneura ; Muscomorpha ; Brachycera ; Diptera ; Endopterygota (cohort); Neoptera (infraclass); Pterygota (subclass); Dicondylia ; Insecta ; Hexapoda ; Pancrustacea ; Mandibulata ; Arthropoda ; Panarthropoda ; Ecdysozoa ; Protostomia ; Bilateria ; Eumetazoa ; Metazoa ; Opisthokonta ; Eukaryota ; cellular organisms
Subcellular Locationsecreted
Developmental StageNA
SimilarityFMRFamide related peptide family
Tissue SpecificityNA
Post Translational ModificationT12 Phenylalanine amide
FunctionBe active on both ASIC channels and nicotinic acetylcholine receptors (nAChRs). Potentiates ASIC1a. Inhibits desensitization of ASIC1a and to a lesser degree ASIC3 currents; resulting in a sustained opening of channels in the presence of low pH . Inhibits with a slow reversibility human alpha-7/CHRNA7 nAChRs and with a rapid reversibility human alpha-1-beta-1-delta-epsilon (CHRNA1-CHRNB1-CHRND-CHRNE) nAChRs
Length9
Molecular Weight1
NameConorfamide-As2a
SequenceRIRKPIFAFPRF
Sequence mapNA
PDB IDNA
DrugpediaNA
ReceptorNA
DomainNA
Pharmaceutical UseNA