| Primary information |
|---|
| ID | 14307 |
| Uniprot ID | P26339 |
| Description | Pyrokinin-1 (Cam-PK-1) (FXPRL-Amide) |
| Organism | Mus musculus |
| Txonomy | Carausius ; Lonchodinae ; Lonchodidae ; Anareolatae ; Verophasmatodea ; Phasmatodea ; Polyneoptera (cohort); Neoptera (infraclass); Pterygota (subclass); Dicondylia ; Insecta ; Hexapoda ; Pancrustacea ; Mandibulata ; Arthropoda ; Panarthropoda ; Ecdysozoa ; Protostomia ; Bilateria ; Eumetazoa ; Metazoa ; Opisthokonta ; Eukaryota ; cellular organisms |
| Subcellular Location | secreted |
| Developmental Stage | NA |
| Similarity | Chromogranin/secretogranin protein family |
| Tissue Specificity | NA |
| Post Translational Modification | T20 Phosphoserine |
| Function | Regulates granule biogenesis in endocrine cells by up-regulating the transcription of protease nexin 1 (SERPINE2) via a cAMP-PKA-SP1 pathway. This leads to inhibition of granule protein degradation in the Golgi complex which in turn promotes granule formation. Pyroglutaminated (pGlu)-serpinin exerts an antiapoptotic effect on cells exposed to oxidative stress. |
| Length | 11 |
| Molecular Weight | 1 |
| Name | Serpinin |
| Sequence | AEDQELESLSAIEAELEKVAHQLQAL |
| Sequence map | NA |
| PDB ID | NA |
| Drugpedia | NA |
| Receptor | NA |
| Domain | NA |
| Pharmaceutical Use | NA
|