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13734 details
Primary information
ID13734
Uniprot IDQ9YHV4
DescriptionFollistatin-A (FS) (Activin-binding protein) (Follistatin-1) (zFst1)
OrganismDanio rerio
TxonomyEukaryota; Opisthokonta; Metazoa; Eumetazoa; Bilateria; Deuterostomia; Chordata; Craniata; Vertebrata; Gnathostomata (jawed vertebrates); Teleostomi; Euteleostomi; Actinopterygii; Actinopteri; Neopterygii; Teleostei; Osteoglossocephalai; Clupeocephala; Otomorpha; Ostariophysi; Otophysi; Cypriniphysae; Cypriniformes (carps and others); Cyprinoidei; Danionidae; Danioninae; Danio; Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular LocationNA
Developmental StageFirst expressed at mid-gastrulation.
SimilarityNA
Tissue SpecificityNot expressed in the organizer region. Expression in gastrulating embryos is confined to anterior and paraxial regions; which give rise to head mesoderm and the first five somites. In addition; expres
Post Translational ModificationNA
FunctionBinds directly to activin and functions as an activin antagonist. Specific inhibitor of the biosynthesis and secretion of pituitary follicle stimulating hormone (fsh). Inhibits bmp-signaling during later stages of development including late phases of dorsoventral patterning; to refine the early pattern set up by the interaction of chordino and bmp2/4. Not involved in organizer function or early phases of dorsoventral pattern formation.
Length322
Molecular Weight35
NameFollistatin-A
SequenceNCWLQQGKNGRCQVLYMPGMSREECCRSGRLGTSWTEEDVPNSTLFRWMIFNGGAPNCIPCKETCDNVDCGPGKRCKMNRRSKPRCVCAPDCSNVTWKGPVCGSDGKTYRDECALLKSKCKGHPDLEVQYQGKCKKTCRDVLCPGSSTCVVDQTNNAYCVTCNRICPEVMSPDQYLCGNDGIVYASACHLRRATCLLGRSIGVAYEGKCIKAKSCDDIHCSAGKKCLWDAKMSRGRCAVCAESCPESRSEEAVCASDNTTYPSECAMKQAACSLGVLLEVKHSGSCNCK
Sequence map38-22
PDB IDNA
DrugpediaNA
ReceptorNA
DomainNA
Pharmaceutical UseNA