| Primary information |
|---|
| ID | 13635 |
| Uniprot ID | A0A0B5AC86 |
| Description | Con-Ins G3b (Insulin 3b) [Cleaved into- Con-Ins G3b B chain; Con-Ins G3b A chain] |
| Organism | Conus geographus |
| Txonomy | Eukaryota; Opisthokonta; Metazoa; Eumetazoa; Bilateria; Protostomia; Spiralia; Lophotrochozoa; Mollusca; Gastropoda; Caenogastropoda; Neogastropoda; Conoidea; Conidae (cone shells); Conus; Gastridium; Conus geographus (Geography cone) (Nubecula geographus) |
| Subcellular Location | Secreted |
| Developmental Stage | NA |
| Similarity | Belongs to the insulin family. |
| Tissue Specificity | Expressed by the venom gland. |
| Post Translational Modification | It is noteworthy that in this dimer; in contrast to Con-Ins G1; the chain B is amidated and not the chain A. |
| Function | This venom insulin; from a fish-hunting cone snail; facilitates prey capture by rapidly inducing hypoglycemic shock. It is one of the smallest known insulin found in nature and lacks the C-terminal segment of the B chain that; in human insulin; mediates engagement of the insulin receptor and assembly of the hormone's hexameric storage form. Despite lacking this segment; it both binds and activates human insulin receptor (long isoform (HIR-B)) with only a 10-fold lower potency. In vivo; intraperitoneal injection of this peptide into zebrafish lowers blood glucose with the same potency than human insulin. In addition; when applied to water; this peptide reduces overall locomotor activity of zebrafish larvae; observed as a significant decrease in the percentage of time spent swimming and movement frequency. |
| Length | 113 |
| Molecular Weight | 12 |
| Name | NA |
| Sequence | NA |
| Sequence map | NA |
| PDB ID | NA |
| Drugpedia | NA |
| Receptor | NA |
| Domain | NA |
| Pharmaceutical Use | NA
|