Detailed description page of Hmrbase2

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13629 details
Primary information
ID13629
Uniprot IDP30371
DescriptionTransforming growth factor beta-2 proprotein [Cleaved into- Latency-associated peptide (LAP); Transforming growth factor beta-2 (TGF-beta-2)]
OrganismGallus gallus
TxonomyEukaryota; Opisthokonta; Metazoa; Eumetazoa; Bilateria; Deuterostomia; Chordata; Craniata; Vertebrata; Gnathostomata (jawed vertebrates); Teleostomi; Euteleostomi; Sarcopterygii; Dipnotetrapodomorpha; Tetrapoda; Amniota; Sauropsida; Sauria (diapsids); Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae (turkeys); Phasianinae; Gallus; Gallus gallus (Chicken)
Subcellular Location[Latency-associated peptide]- Secreted; extracellular space; extracellular matrix
Developmental StageNA
SimilarityBelongs to the TGF-beta family.
Tissue SpecificityNA
Post Translational ModificationTransforming growth factor beta-2 proprotein- The precursor proprotein is cleaved in the Golgi apparatus to form Transforming growth factor beta-2 (TGF-beta-2) and Latency-associated peptide (LAP) cha
FunctionTransforming growth factor beta-2 proprotein- Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-2 (TGF-beta-2) chains; which constitute the regulatory and active subunit of TGF-beta-2; respectively.
Length412
Molecular Weight47
NameTransforming growth factor beta-2 proprotein
SequenceSTCSTLDMDQFMRKRIEAIRGQILSKLKLTSPPDEYPEPEEVPPEVISIYNSTRDLLQEKANHRAATCERERSDEEYYAKEVYKIDMQPFYPENAIPPSYYSLYFRIVRFDVSAMEKNASNLVKAEFRVFRLQNSKARVSEQRIELYQVLKSKELSSPGQRYIDSKVVKTRAEGEWLSFDVTEAVHEWLHHRDRNLGFKISLHCPCCTFVPSNNYIIPNKSEEPEARFAGIDDYTYSSGDVKALKSNRKKYSGKTPHLLLMLLPSYRLESQQPSRRKKRALDAAYCFRNVQDNCCLRPLYIDFKRDLGWKWIHEPKGYHANFCAGACPYLWSSDTQHSRVLSLYNTINPEASASPCCVSQDLEPLTILYYIGKTPKIEQLSNMIVKSCKCS
Sequence map27-52
PDB IDNA
DrugpediaNA
ReceptorNA
DomainNA
Pharmaceutical UseNA