Detailed description page of Hmrbase2

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13628 details
Primary information
ID13628
Uniprot IDC6EVG7
DescriptionNatriuretic and helokinestatin peptides [Cleaved into- Helokinestatin-1 (HKS-1); Helokinestatin-2 (HKS-2); Helokinestatin-3 (HKS-3); Helokinestatin-4 (HKS-4); Natriuretic peptide]
OrganismHeloderma suspectum cinctum
TxonomyEukaryota; Opisthokonta; Metazoa; Eumetazoa; Bilateria; Deuterostomia; Chordata; Craniata; Vertebrata; Gnathostomata (jawed vertebrates); Teleostomi; Euteleostomi; Sarcopterygii; Dipnotetrapodomorpha; Tetrapoda; Amniota; Sauropsida; Sauria (diapsids); Lepidosauria (lepidosaurs); Squamata (squamates); Bifurcata (split-tongued squamates); Unidentata; Episquamata; Toxicofera; Anguimorpha (anguimorph lizards); Neoanguimorpha (New World anguimorph lizards); Helodermatidae (beaded lizards); Heloderma;
Subcellular LocationSecreted
Developmental StageNA
SimilarityIn the C-terminal section; belongs to the natriuretic peptide family.
Tissue SpecificityExpressed by the venom gland.
Post Translational ModificationNA
FunctionHelokinestatin antagonizes the vasodilatory actions of bradykinin at the B2 bradykinin receptor (BDKRB2); with helokinestatin-1 being the most potent antagonist.
Length178
Molecular Weight19
NameNA
SequenceNA
Sequence mapNA
PDB IDNA
DrugpediaNA
ReceptorNA
DomainNA
Pharmaceutical UseNA