| Primary information |
|---|
| ID | 13610 |
| Uniprot ID | O96690 |
| Description | Protein PDF [Cleaved into- PDF precursor-related peptide (PAP); Neuropeptide PDF (Pigment-dispersing factor homolog)] |
| Organism | Drosophila melanogaster |
| Txonomy | Eukaryota; Opisthokonta; Metazoa; Eumetazoa; Bilateria; Protostomia; Ecdysozoa; Panarthropoda; Arthropoda; Mandibulata; Pancrustacea; Hexapoda; Insecta; Dicondylia; Pterygota (winged insects); Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Eremoneura; Cyclorrhapha; Schizophora; Acalyptratae; Ephydroidea; Drosophilidae (pomace flies); Drosophilinae; Drosophilini; Drosophila (fruit flies); Sophophora; melanogaster group; melanogaster subgroup; Drosophila melanogaster (Fruit fly) |
| Subcellular Location | Secreted |
| Developmental Stage | Expressed at constant level; without strong circadian variations. Its amount nevertheless oscillates along day and night cycles in the termini of dorsally projected axons of LNvs. |
| Similarity | Belongs to the arthropod PDH family. |
| Tissue Specificity | Predominantly expressed in adult head. Expressed at higher level in males than in females. In adult brain; it is specifically expressed in the ventral lateral neurons (LNvs) as well as in 2-4 tritocer |
| Post Translational Modification | NA |
| Function | Neuropeptide PDF is the main transmitter regulating circadian locomotor rhythms. Required to maintain behavioral rhythms under constant conditions by coordinating pacemaker interactions in the circadian system. Ectopic expression induces long periods; while its absence leads to short periods. Acts on small and large ventral lateral neurons to control sleep and regulates the state transition from sleep to wake |
| Length | 102 |
| Molecular Weight | 11 |
| Name | NA |
| Sequence | NA |
| Sequence map | NA |
| PDB ID | NA |
| Drugpedia | NA |
| Receptor | NA |
| Domain | NA |
| Pharmaceutical Use | NA
|