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13599 details
Primary information
ID13599
Uniprot IDP02761
DescriptionMajor urinary protein (MUP) (Allergen Rat n I) (Alpha(2)-euglobulin) (Alpha-2u-globulin) (alpha-2u globulin PGCL1) (allergen Rat n 1) [Cleaved into- 15.5 kDa fatty acid-binding protein (15.5 kDa FABP)]
OrganismRattus norvegicus
TxonomyEukaryota; Opisthokonta; Metazoa; Eumetazoa; Bilateria; Deuterostomia; Chordata; Craniata; Vertebrata; Gnathostomata (jawed vertebrates); Teleostomi; Euteleostomi; Sarcopterygii; Dipnotetrapodomorpha; Tetrapoda; Amniota; Mammalia; Theria; Eutheria; Boreoeutheria; Euarchontoglires; Glires (Rodents and rabbits); Rodentia; Myomorpha (mice and others); Muroidea; Muridae; Murinae; Rattus; Rattus norvegicus (Rat)
Subcellular Location[15.5 kDa fatty acid-binding protein]- Cytoplasm; cytosol. Note=It is probably taken up from the uri
Developmental StageNA
SimilarityBelongs to the calycin superfamily. Lipocalin family.
Tissue SpecificityAbundant in the urine of adult male rats but absent from that of females.
Post Translational ModificationNA
FunctionMajor urinary proteins (Mups) bind and release pheromones. They may also protect pheromones from oxidation. In this context; they play a role in the regulation of social behaviors; such as aggression; mating; pup-suckling; territory establishment and dominance. Acts as a kairomone; detected by the prey vomeronasal organ and inducing fear reactions in mice.
Length181
Molecular Weight20
NameMajor urinary protein
SequenceEASSTRGNLDVAKLNGDWFSIVVASNKREKIEENGSMRVFMQHIDVLENSLGFKFRIKENGECRELYLVAYKTPEDGEYFVEYDGGNTFTILKTDYDRYVMFHLINFKNGETFQLMVLYGRTKDLSSDIKEKFAKLCEAHGITRDNIIDLTKTDRCLQARG
Sequence map23-01
PDB ID2A2G; 2A2U;
DrugpediaNA
ReceptorNA
DomainNA
Pharmaceutical UseNA