| Primary information |
|---|
| ID | 13593 |
| Uniprot ID | B2KKR4 |
| Description | Pro-FMRFamide-related neuropeptide VF (FMRFamide-related peptides) [Cleaved into- Neuropeptide NPSF; Neuropeptide RFRP-1; Neuropeptide RFRP-2; Neuropeptide NPVF (Neuropeptide RFRP-3)] |
| Organism | Ovis aries |
| Txonomy | Eukaryota; Opisthokonta; Metazoa; Eumetazoa; Bilateria; Deuterostomia; Chordata; Craniata; Vertebrata; Gnathostomata (jawed vertebrates); Teleostomi; Euteleostomi; Sarcopterygii; Dipnotetrapodomorpha; Tetrapoda; Amniota; Mammalia; Theria; Eutheria; Boreoeutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Caprinae; Ovis; Ovis aries (Sheep) |
| Subcellular Location | Secreted |
| Developmental Stage | NA |
| Similarity | Belongs to the FARP (FMRFamide related peptide) family. |
| Tissue Specificity | Expressed in hypothalamus; where it is localized to the dorsomedial hypothalamic nucleus (DMH); paraventricular nucleus (PVN); and to neuronal projections from the PVN to the neurosecretory zone of th |
| Post Translational Modification | NA |
| Function | Neuropeptide RFRP-1 acts as a potent negative regulator of gonadotropin synthesis and secretion. Neuropeptides NPSF and NPVF efficiently inhibit forskolin-induced production of cAMP; but RFRP-2 shows no inhibitory activity. Neuropeptide NPVF blocks morphine-induced analgesia. May act in concert with kisspeptin; through opposing affects; to regulate the activity of gonadotropin-releasing hormone (GnRH) neurons across the seasons; leading to an annual change in fertility and the cyclical seasonal transition from non-breeding to breeding season. |
| Length | 196 |
| Molecular Weight | 22 |
| Name | NA |
| Sequence | NA |
| Sequence map | NA |
| PDB ID | NA |
| Drugpedia | NA |
| Receptor | NA |
| Domain | NA |
| Pharmaceutical Use | NA
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