Detailed description page of Hmrbase2

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13584 details
Primary information
ID13584
Uniprot IDQ9WUK0
DescriptionInsulin-like 3 (Leydig insulin-like peptide) (Ley-I-L) (Relaxin-like factor) [Cleaved into- Insulin-like 3 B chain; Insulin-like 3 A chain]
OrganismRattus norvegicus
TxonomyEukaryota; Opisthokonta; Metazoa; Eumetazoa; Bilateria; Deuterostomia; Chordata; Craniata; Vertebrata; Gnathostomata (jawed vertebrates); Teleostomi; Euteleostomi; Sarcopterygii; Dipnotetrapodomorpha; Tetrapoda; Amniota; Mammalia; Theria; Eutheria; Boreoeutheria; Euarchontoglires; Glires (Rodents and rabbits); Rodentia; Myomorpha (mice and others); Muroidea; Muridae; Murinae; Rattus; Rattus norvegicus (Rat)
Subcellular LocationSecreted
Developmental StageHighly expressed in adult testis and low expression in the ovary. Highly up-regulated in testes of day 19 embryos; but not in later neonatal stages; nor any ovarian tissue from this period.
SimilarityBelongs to the insulin family.
Tissue SpecificityExpressed in Leydig cells of the testis; and weakly in the theca interna cells of antral follicles and the corpus luteum of the ovary.
Post Translational ModificationNA
FunctionSeems to play a role in testicular function. May be a trophic hormone with a role in testicular descent in fetal life. Is a ligand for LGR8 receptor.
Length128
Molecular Weight14
NameNA
SequenceNA
Sequence mapNA
PDB IDNA
DrugpediaNA
ReceptorNA
DomainNA
Pharmaceutical UseNA