Primary information |
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ID | 13584 |
Uniprot ID | Q9WUK0 |
Description | Insulin-like 3 (Leydig insulin-like peptide) (Ley-I-L) (Relaxin-like factor) [Cleaved into- Insulin-like 3 B chain; Insulin-like 3 A chain] |
Organism | Rattus norvegicus |
Txonomy | Eukaryota; Opisthokonta; Metazoa; Eumetazoa; Bilateria; Deuterostomia; Chordata; Craniata; Vertebrata; Gnathostomata (jawed vertebrates); Teleostomi; Euteleostomi; Sarcopterygii; Dipnotetrapodomorpha; Tetrapoda; Amniota; Mammalia; Theria; Eutheria; Boreoeutheria; Euarchontoglires; Glires (Rodents and rabbits); Rodentia; Myomorpha (mice and others); Muroidea; Muridae; Murinae; Rattus; Rattus norvegicus (Rat) |
Subcellular Location | Secreted |
Developmental Stage | Highly expressed in adult testis and low expression in the ovary. Highly up-regulated in testes of day 19 embryos; but not in later neonatal stages; nor any ovarian tissue from this period. |
Similarity | Belongs to the insulin family. |
Tissue Specificity | Expressed in Leydig cells of the testis; and weakly in the theca interna cells of antral follicles and the corpus luteum of the ovary. |
Post Translational Modification | NA |
Function | Seems to play a role in testicular function. May be a trophic hormone with a role in testicular descent in fetal life. Is a ligand for LGR8 receptor. |
Length | 128 |
Molecular Weight | 14 |
Name | NA |
Sequence | NA |
Sequence map | NA |
PDB ID | NA |
Drugpedia | NA |
Receptor | NA |
Domain | NA |
Pharmaceutical Use | NA
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