| Primary information |
|---|
| ID | 13584 |
| Uniprot ID | Q9WUK0 |
| Description | Insulin-like 3 (Leydig insulin-like peptide) (Ley-I-L) (Relaxin-like factor) [Cleaved into- Insulin-like 3 B chain; Insulin-like 3 A chain] |
| Organism | Rattus norvegicus |
| Txonomy | Eukaryota; Opisthokonta; Metazoa; Eumetazoa; Bilateria; Deuterostomia; Chordata; Craniata; Vertebrata; Gnathostomata (jawed vertebrates); Teleostomi; Euteleostomi; Sarcopterygii; Dipnotetrapodomorpha; Tetrapoda; Amniota; Mammalia; Theria; Eutheria; Boreoeutheria; Euarchontoglires; Glires (Rodents and rabbits); Rodentia; Myomorpha (mice and others); Muroidea; Muridae; Murinae; Rattus; Rattus norvegicus (Rat) |
| Subcellular Location | Secreted |
| Developmental Stage | Highly expressed in adult testis and low expression in the ovary. Highly up-regulated in testes of day 19 embryos; but not in later neonatal stages; nor any ovarian tissue from this period. |
| Similarity | Belongs to the insulin family. |
| Tissue Specificity | Expressed in Leydig cells of the testis; and weakly in the theca interna cells of antral follicles and the corpus luteum of the ovary. |
| Post Translational Modification | NA |
| Function | Seems to play a role in testicular function. May be a trophic hormone with a role in testicular descent in fetal life. Is a ligand for LGR8 receptor. |
| Length | 128 |
| Molecular Weight | 14 |
| Name | NA |
| Sequence | NA |
| Sequence map | NA |
| PDB ID | NA |
| Drugpedia | NA |
| Receptor | NA |
| Domain | NA |
| Pharmaceutical Use | NA
|