| Primary information |
|---|
| ID | 13574 |
| Uniprot ID | P84715 |
| Description | C-type natriuretic peptide (CNP) [Cleaved into- Venom peptide 1; Venom peptide 2; Venom peptide 3; Venom peptide 4; Venom peptide 5; Venom peptide 6; Venom peptide 7; Venom peptide 8; Venom peptide 9; Venom peptide 10; Venom peptide 11; C-type natriuretic peptide 39 (ovCNP-39)] |
| Organism | Ornithorhynchus anatinus |
| Txonomy | Eukaryota; Opisthokonta; Metazoa; Eumetazoa; Bilateria; Deuterostomia; Chordata; Craniata; Vertebrata; Gnathostomata (jawed vertebrates); Teleostomi; Euteleostomi; Sarcopterygii; Dipnotetrapodomorpha; Tetrapoda; Amniota; Mammalia; Prototheria; Monotremata (egg-laying mammals); Ornithorhynchidae; Ornithorhynchus; Ornithorhynchus anatinus (Duckbill platypus) |
| Subcellular Location | Secreted |
| Developmental Stage | NA |
| Similarity | In the C-terminal section; belongs to the natriuretic peptide family. |
| Tissue Specificity | Expressed by the venom gland. |
| Post Translational Modification | Stereoinversion of L-Leu-84 (in ovCNP-39a) to D-Leu-84 (in ovCNP-39b). |
| Function | Venom component with vasorelaxant activity. In vitro stimulates the production of cGMP in rat aortic smooth muscle cells and histamine release from rat peritoneal mast cells. Induces relaxation of isolated rat uterus. Induces local edema following subplantar injection into rat hind paw. Forms voltage-dependent cation channels which are weakly selective for potassium relative to sodium; and whose conductance decreases with increasing dehydration energy of the monovalent cation. The activity of the fast cation channels is calcium dependent and is characterized by short bursts of current separated by long periods of inactivation. |
| Length | 121 |
| Molecular Weight | 13 |
| Name | NA |
| Sequence | NA |
| Sequence map | NA |
| PDB ID | NA |
| Drugpedia | NA |
| Receptor | NA |
| Domain | NA |
| Pharmaceutical Use | NA
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