| Primary information |
|---|
| ID | 13558 |
| Uniprot ID | Q9PW56 |
| Description | Bradykinin-potentiating and C-type natriuretic peptides (Brain BPP-CNP) (bBPP-CNP) (Evasin-CNP) [Cleaved into- Bradykinin-potentiating peptide 13a+QQWA (BPP-13a+QQWA); Bradykinin-potentiating peptide 13a+QWA (BPP-13a+QWA); Bradykinin-potentiating peptide 13a (BPP-13a); Bradykinin-potentiating peptid |
| Organism | Bothrops jararaca |
| Txonomy | Eukaryota; Opisthokonta; Metazoa; Eumetazoa; Bilateria; Deuterostomia; Chordata; Craniata; Vertebrata; Gnathostomata (jawed vertebrates); Teleostomi; Euteleostomi; Sarcopterygii; Dipnotetrapodomorpha; Tetrapoda; Amniota; Sauropsida; Sauria (diapsids); Lepidosauria (lepidosaurs); Squamata (squamates); Bifurcata (split-tongued squamates); Unidentata; Episquamata; Toxicofera; Serpentes (snakes); Colubroidea; Viperidae; Crotalinae (pit vipers); Bothrops; Bothrops jararaca (Jararaca) (Bothrops jajara |
| Subcellular Location | Secreted Cytoplasm; cytosol. Note=BPP-10c is internalized in the cytosol of prey cells. |
| Developmental Stage | BPP-10a; BPP-10c+QQWA; BPP-AP; BPP-13A; BPP-13a+QWA and BPP-13a+QQWA seem to be found in both adult and newborn B.jararaca venoms; whereas BPP-APL seem to be only present in newborn venom. |
| Similarity | In the N-terminal section; belongs to the bradykinin-potentiating peptide family. |
| Tissue Specificity | Adult brain regions; ventromedial hypothalamus; paraventricular nucleus; paraventricular organ; and the subcommissural organ. Also expressed by the venom gland. |
| Post Translational Modification | NA |
| Function | [Bradykinin-potentiating peptide 5a]- modestly inhibits ACE (with highest affinity for the N-site) and reveals strong bradykinin-potentiating activity. Induces nitric oxide (NO) production depended on muscarinic acetylcholine receptor M1 subtype (CHRM1) and bradykinin B2 receptor (BDKRB2) activation. Both these receptors contribute to the vasodilation induced by this peptide that may have an indirect action on BDKRB2 and a direct agonistic action on CHRM1.; [Bradykinin-potentiating peptide 10c]- peptide with several activities. It inhibits the activity of the angiotensin-converting enzyme (ACE) by a preferential interaction with its C-domain |
| Length | 265 |
| Molecular Weight | 27 |
| Name | NA |
| Sequence | NA |
| Sequence map | NA |
| PDB ID | NA |
| Drugpedia | NA |
| Receptor | NA |
| Domain | NA |
| Pharmaceutical Use | NA
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