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13535 details
Primary information
ID13535
Uniprot IDA0A0B5A7P2
DescriptionCon-Ins G1c (Insulin 1c) [Cleaved into- Con-Ins G1 B chain; Con-Ins G1c A chain]
OrganismConus geographus
TxonomyEukaryota; Opisthokonta; Metazoa; Eumetazoa; Bilateria; Protostomia; Spiralia; Lophotrochozoa; Mollusca; Gastropoda; Caenogastropoda; Neogastropoda; Conoidea; Conidae (cone shells); Conus; Gastridium; Conus geographus (Geography cone) (Nubecula geographus)
Subcellular LocationSecreted
Developmental StageNA
SimilarityBelongs to the insulin family.
Tissue SpecificityExpressed by the venom gland.
Post Translational ModificationIs different from Con-Ins G1a (AC A0A0B5AC95) due to absence of amidation at Cys-114.
FunctionThis venom insulin; from a fish-hunting cone snail; facilitates prey capture by rapidly inducing hypoglycemic shock. It is one of the smallest known insulin found in nature and lacks the C-terminal segment of the B chain that; in human insulin; mediates engagement of the insulin receptor and assembly of the hormone's hexameric storage form. Despite lacking this segment; it both binds and activates human insulin receptor (long isoform (HIR-B)) with only a 10-fold lower potency. In vivo; intraperitoneal injection of this peptide into zebrafish lowers blood glucose with the same potency than human insulin. In addition; when applied to water; this peptide reduces overall locomotor activity of zebrafish larvae; observed as a significant decrease in the percentage of time spent swimming and movement frequency.
Length115
Molecular Weight13
NameNA
SequenceNA
Sequence mapNA
PDB IDNA
DrugpediaNA
ReceptorNA
DomainNA
Pharmaceutical UseNA