Primary information |
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ID | 13535 |
Uniprot ID | A0A0B5A7P2 |
Description | Con-Ins G1c (Insulin 1c) [Cleaved into- Con-Ins G1 B chain; Con-Ins G1c A chain] |
Organism | Conus geographus |
Txonomy | Eukaryota; Opisthokonta; Metazoa; Eumetazoa; Bilateria; Protostomia; Spiralia; Lophotrochozoa; Mollusca; Gastropoda; Caenogastropoda; Neogastropoda; Conoidea; Conidae (cone shells); Conus; Gastridium; Conus geographus (Geography cone) (Nubecula geographus) |
Subcellular Location | Secreted |
Developmental Stage | NA |
Similarity | Belongs to the insulin family. |
Tissue Specificity | Expressed by the venom gland. |
Post Translational Modification | Is different from Con-Ins G1a (AC A0A0B5AC95) due to absence of amidation at Cys-114. |
Function | This venom insulin; from a fish-hunting cone snail; facilitates prey capture by rapidly inducing hypoglycemic shock. It is one of the smallest known insulin found in nature and lacks the C-terminal segment of the B chain that; in human insulin; mediates engagement of the insulin receptor and assembly of the hormone's hexameric storage form. Despite lacking this segment; it both binds and activates human insulin receptor (long isoform (HIR-B)) with only a 10-fold lower potency. In vivo; intraperitoneal injection of this peptide into zebrafish lowers blood glucose with the same potency than human insulin. In addition; when applied to water; this peptide reduces overall locomotor activity of zebrafish larvae; observed as a significant decrease in the percentage of time spent swimming and movement frequency. |
Length | 115 |
Molecular Weight | 13 |
Name | NA |
Sequence | NA |
Sequence map | NA |
PDB ID | NA |
Drugpedia | NA |
Receptor | NA |
Domain | NA |
Pharmaceutical Use | NA
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