| Primary information |
|---|
| ID | 13534 |
| Uniprot ID | A0A0B5AC90 |
| Description | Con-Ins T1B (Con-Ins T2) (Insulin 2) [Cleaved into- Con-Ins T1B B chain (Con-Ins T2 B chain); Con-Ins T1B A chain (Con-Ins T2 A chain)] |
| Organism | Conus tulipa |
| Txonomy | Eukaryota; Opisthokonta; Metazoa; Eumetazoa; Bilateria; Protostomia; Spiralia; Lophotrochozoa; Mollusca; Gastropoda; Caenogastropoda; Neogastropoda; Conoidea; Conidae (cone shells); Conus; Gastridium; Conus tulipa (Fish-hunting cone snail) (Tulip cone) |
| Subcellular Location | Secreted |
| Developmental Stage | NA |
| Similarity | Belongs to the insulin family. |
| Tissue Specificity | Expressed by the venom gland. |
| Post Translational Modification | NA |
| Function | This venom insulin; from a fish-hunting cone snail; facilitates prey capture by rapidly inducing hypoglycemic shock. It is one of the smallest known insulin found in nature and lacks the C-terminal segment of the B chain that; in human insulin; mediates engagement of the insulin receptor and assembly of the hormone's hexameric storage form. Despite lacking this segment; it both binds and activates human insulin receptor (long isoform (HIR-B)) with a high potency (EC(50)=12.0 nM) |
| Length | 115 |
| Molecular Weight | 13 |
| Name | NA |
| Sequence | NA |
| Sequence map | NA |
| PDB ID | NA |
| Drugpedia | NA |
| Receptor | NA |
| Domain | NA |
| Pharmaceutical Use | NA
|