Primary information |
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ID | 13534 |
Uniprot ID | A0A0B5AC90 |
Description | Con-Ins T1B (Con-Ins T2) (Insulin 2) [Cleaved into- Con-Ins T1B B chain (Con-Ins T2 B chain); Con-Ins T1B A chain (Con-Ins T2 A chain)] |
Organism | Conus tulipa |
Txonomy | Eukaryota; Opisthokonta; Metazoa; Eumetazoa; Bilateria; Protostomia; Spiralia; Lophotrochozoa; Mollusca; Gastropoda; Caenogastropoda; Neogastropoda; Conoidea; Conidae (cone shells); Conus; Gastridium; Conus tulipa (Fish-hunting cone snail) (Tulip cone) |
Subcellular Location | Secreted |
Developmental Stage | NA |
Similarity | Belongs to the insulin family. |
Tissue Specificity | Expressed by the venom gland. |
Post Translational Modification | NA |
Function | This venom insulin; from a fish-hunting cone snail; facilitates prey capture by rapidly inducing hypoglycemic shock. It is one of the smallest known insulin found in nature and lacks the C-terminal segment of the B chain that; in human insulin; mediates engagement of the insulin receptor and assembly of the hormone's hexameric storage form. Despite lacking this segment; it both binds and activates human insulin receptor (long isoform (HIR-B)) with a high potency (EC(50)=12.0 nM) |
Length | 115 |
Molecular Weight | 13 |
Name | NA |
Sequence | NA |
Sequence map | NA |
PDB ID | NA |
Drugpedia | NA |
Receptor | NA |
Domain | NA |
Pharmaceutical Use | NA
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