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13534 details
Primary information
ID13534
Uniprot IDA0A0B5AC90
DescriptionCon-Ins T1B (Con-Ins T2) (Insulin 2) [Cleaved into- Con-Ins T1B B chain (Con-Ins T2 B chain); Con-Ins T1B A chain (Con-Ins T2 A chain)]
OrganismConus tulipa
TxonomyEukaryota; Opisthokonta; Metazoa; Eumetazoa; Bilateria; Protostomia; Spiralia; Lophotrochozoa; Mollusca; Gastropoda; Caenogastropoda; Neogastropoda; Conoidea; Conidae (cone shells); Conus; Gastridium; Conus tulipa (Fish-hunting cone snail) (Tulip cone)
Subcellular LocationSecreted
Developmental StageNA
SimilarityBelongs to the insulin family.
Tissue SpecificityExpressed by the venom gland.
Post Translational ModificationNA
FunctionThis venom insulin; from a fish-hunting cone snail; facilitates prey capture by rapidly inducing hypoglycemic shock. It is one of the smallest known insulin found in nature and lacks the C-terminal segment of the B chain that; in human insulin; mediates engagement of the insulin receptor and assembly of the hormone's hexameric storage form. Despite lacking this segment; it both binds and activates human insulin receptor (long isoform (HIR-B)) with a high potency (EC(50)=12.0 nM)
Length115
Molecular Weight13
NameNA
SequenceNA
Sequence mapNA
PDB IDNA
DrugpediaNA
ReceptorNA
DomainNA
Pharmaceutical UseNA