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13522 details
Primary information
ID13522
Uniprot IDA0A0B5ABD5
DescriptionCon-Ins T3 (Insulin 3) [Cleaved into- Con-Ins T3 B chain; Con-Ins T3 A chain]
OrganismConus tulipa
TxonomyEukaryota; Opisthokonta; Metazoa; Eumetazoa; Bilateria; Protostomia; Spiralia; Lophotrochozoa; Mollusca; Gastropoda; Caenogastropoda; Neogastropoda; Conoidea; Conidae (cone shells); Conus; Gastridium; Conus tulipa (Fish-hunting cone snail) (Tulip cone)
Subcellular LocationSecreted
Developmental StageNA
SimilarityBelongs to the insulin family.
Tissue SpecificityExpressed by the venom gland.
Post Translational ModificationNA
FunctionThis venom insulin facilitates prey capture by rapidly inducing hypoglycemic shock. It is one of the smallest known insulin found in nature and lacks the C-terminal segment of the B chain that; in human insulin; mediates engagement of the insulin receptor and assembly of the hormone's hexameric storage form. Despite lacking this segment; it both binds and activates human insulin receptor (long isoform (HIR-B)) with only a 10-fold lower potency. In vivo; intraperitoneal injection of this peptide into zebrafish lowers blood glucose with the same potency than human insulin. In addition; when applied to water; this peptide reduces overall locomotor activity of zebrafish larvae; observed as a significant decrease in the percentage of time spent swimming and movement frequency.
Length117
Molecular Weight13
NameNA
SequenceNA
Sequence mapNA
PDB IDNA
DrugpediaNA
ReceptorNA
DomainNA
Pharmaceutical UseNA