| Primary information |
|---|
| ID | 13514 |
| Uniprot ID | Q9R0R4 |
| Description | Apelin (APJ endogenous ligand) [Cleaved into- Apelin-36; Apelin-31; Apelin-28; Apelin-13] |
| Organism | Mus musculus |
| Txonomy | Eukaryota; Opisthokonta; Metazoa; Eumetazoa; Bilateria; Deuterostomia; Chordata; Craniata; Vertebrata; Gnathostomata (jawed vertebrates); Teleostomi; Euteleostomi; Sarcopterygii; Dipnotetrapodomorpha; Tetrapoda; Amniota; Mammalia; Theria; Eutheria; Boreoeutheria; Euarchontoglires; Glires (Rodents and rabbits); Rodentia; Myomorpha (mice and others); Muroidea; Muridae; Murinae; Mus; Mus; Mus musculus (Mouse) |
| Subcellular Location | Secreted |
| Developmental Stage | NA |
| Similarity | Belongs to the apelin family. |
| Tissue Specificity | Expressed in extraembryonic visceral endoderm and in the primitive streak at 6.5 and 7.5 dpc (PubMed-28854362). Expressed in the anterior visceral yolk sac at 8.25 dpc (PubMed-28854362). Expressed wea |
| Post Translational Modification | Several active peptides may be produced by proteolytic processing of the peptide precursor. |
| Function | Endogenous ligand for the apelin receptor (APLNR). Drives internalization of APLNR. Apelin-36 dissociates more hardly than (pyroglu)apelin-13 from APLNR. Hormone involved in the regulation of cardiac precursor cell movements during gastrulation and heart morphogenesis. Has an inhibitory effect on cytokine production in response to T-cell receptor/CD3 cross-linking; the oral intake of apelin in the colostrum and the milk might therefore modulate immune responses in neonates |
| Length | 77 |
| Molecular Weight | 8 |
| Name | NA |
| Sequence | NA |
| Sequence map | NA |
| PDB ID | NA |
| Drugpedia | NA |
| Receptor | NA |
| Domain | NA |
| Pharmaceutical Use | NA
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