Primary information |
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ID | 13482 |
Uniprot ID | P83059 |
Description | Kininogen-2 (BOK-2) [Cleaved into- [Thr6]-bradykinin; Bradykinin inhibitor peptide DV-28 (DV-28 amide)] |
Organism | Bombina orientalis |
Txonomy | Eukaryota; Opisthokonta; Metazoa; Eumetazoa; Bilateria; Deuterostomia; Chordata; Craniata; Vertebrata; Gnathostomata (jawed vertebrates); Teleostomi; Euteleostomi; Sarcopterygii; Dipnotetrapodomorpha; Tetrapoda; Amphibia; Batrachia; Anura; Bombinatoridae; Bombina (firebellied toads); Bombina orientalis (Oriental fire-bellied toad) |
Subcellular Location | Secreted |
Developmental Stage | NA |
Similarity | Belongs to the bradykinin-related peptide family. |
Tissue Specificity | Expressed by the skin glands. |
Post Translational Modification | NA |
Function | [[Thr6]-bradykinin]- inhibits ACE with a Ki of 1.6 uM; and targets B2 bradykinin receptor (BDKRB2). Provokes contraction of smooth muscle preparation (ileum). In vivo; induces an early hyperalgesic effects in living rats after intraplantar injection. |
Length | 161 |
Molecular Weight | 19 |
Name | Kininogen-2 |
Sequence | ERNNRDYPIRTHLHGPHIPRNNRDYPIRTHLHGHHIPRNVPESEEKTEQFLRDLSEISRLQRRPPGFTPFRGKFHSQSLRDLSEISRLQRRPPGFTPFRGKFHSQSLRDMYEIKGFKSAHGRPRVCPPGEQCPIWVG |
Sequence map | 26-41 |
PDB ID | NA |
Drugpedia | NA |
Receptor | NA |
Domain | NA |
Pharmaceutical Use | NA
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