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13482 details
Primary information
ID13482
Uniprot IDP83059
DescriptionKininogen-2 (BOK-2) [Cleaved into- [Thr6]-bradykinin; Bradykinin inhibitor peptide DV-28 (DV-28 amide)]
OrganismBombina orientalis
TxonomyEukaryota; Opisthokonta; Metazoa; Eumetazoa; Bilateria; Deuterostomia; Chordata; Craniata; Vertebrata; Gnathostomata (jawed vertebrates); Teleostomi; Euteleostomi; Sarcopterygii; Dipnotetrapodomorpha; Tetrapoda; Amphibia; Batrachia; Anura; Bombinatoridae; Bombina (firebellied toads); Bombina orientalis (Oriental fire-bellied toad)
Subcellular LocationSecreted
Developmental StageNA
SimilarityBelongs to the bradykinin-related peptide family.
Tissue SpecificityExpressed by the skin glands.
Post Translational ModificationNA
Function[[Thr6]-bradykinin]- inhibits ACE with a Ki of 1.6 uM; and targets B2 bradykinin receptor (BDKRB2). Provokes contraction of smooth muscle preparation (ileum). In vivo; induces an early hyperalgesic effects in living rats after intraplantar injection.
Length161
Molecular Weight19
NameKininogen-2
SequenceERNNRDYPIRTHLHGPHIPRNNRDYPIRTHLHGHHIPRNVPESEEKTEQFLRDLSEISRLQRRPPGFTPFRGKFHSQSLRDLSEISRLQRRPPGFTPFRGKFHSQSLRDMYEIKGFKSAHGRPRVCPPGEQCPIWVG
Sequence map26-41
PDB IDNA
DrugpediaNA
ReceptorNA
DomainNA
Pharmaceutical UseNA