Detailed description page of Hmrbase2

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13471 details
Primary information
ID13471
Uniprot IDE7EZ53
DescriptionGalanin peptides [Cleaved into- Galanin; Galanin message-associated peptide]
OrganismDanio rerio
TxonomyEukaryota; Opisthokonta; Metazoa; Eumetazoa; Bilateria; Deuterostomia; Chordata; Craniata; Vertebrata; Gnathostomata (jawed vertebrates); Teleostomi; Euteleostomi; Actinopterygii; Actinopteri; Neopterygii; Teleostei; Osteoglossocephalai; Clupeocephala; Otomorpha; Ostariophysi; Otophysi; Cypriniphysae; Cypriniformes (carps and others); Cyprinoidei; Danionidae; Danioninae; Danio; Danio rerio (Zebrafish) (Brachydanio rerio)
Subcellular LocationSecreted
Developmental StageIn embryos and larvae; detected mainly in nerve cells in the preoptic-hypothalamic regions and fibers innervating several brain regions (at protein level) (PubMed-22522977; PubMed-27315774). In embryo
SimilarityBelongs to the galanin family.
Tissue SpecificityStrongly expressed in brain and stomach; moderately in the eye; and very weakly in heart; kidney and gills. Not detected in liver.
Post Translational ModificationNA
FunctionEndocrine hormone of the central and peripheral nervous systems that binds and activates the G protein-coupled receptors GALR1 (galr1a and galr1b) and GALR2 (galr2a and galr2b). This small neuropeptide may regulate diverse physiologic functions including contraction of smooth muscle of the gastrointestinal and genitourinary tract; growth hormone and insulin release and adrenal secretion.
Length118
Molecular Weight12
NameNA
SequenceNA
Sequence mapNA
PDB IDNA
DrugpediaNA
ReceptorNA
DomainNA
Pharmaceutical UseNA