Detailed description page of Hmrbase2

This page displays user query in tabular form.

13424 details
Primary information
ID13424
Uniprot IDO09037
DescriptionRegenerating islet-derived protein 3-alpha (REG-3-alpha) (Islet of Langerhans regenerating protein 3) (Lithostathine 3) (Pancreatitis-associated protein 2) (Regenerating islet-derived protein III-alpha) (Reg III-alpha) [Cleaved into- Regenerating islet-derived protein 3-alpha 16.5 kDa form; Regenera
OrganismMus musculus
TxonomyEukaryota; Opisthokonta; Metazoa; Eumetazoa; Bilateria; Deuterostomia; Chordata; Craniata; Vertebrata; Gnathostomata (jawed vertebrates); Teleostomi; Euteleostomi; Sarcopterygii; Dipnotetrapodomorpha; Tetrapoda; Amniota; Mammalia; Theria; Eutheria; Boreoeutheria; Euarchontoglires; Glires (Rodents and rabbits); Rodentia; Myomorpha (mice and others); Muroidea; Muridae; Murinae; Mus; Mus; Mus musculus (Mouse)
Subcellular LocationSecreted
Developmental StageNA
SimilarityNA
Tissue SpecificitySmall intestine and pancreas.
Post Translational ModificationProteolytic processing by trypsin removes an inhibitory N-terminal propeptide and is essential for its antimicrobial activity.
FunctionBactericidal C-type lectin. Regulates keratinocyte proliferation and differentiation after skin injury via activation of EXTL3-PI3K-AKT signaling pathway.
Length175
Molecular Weight19
NameRegenerating islet-derived protein 3-alpha 16.5 kDa form
SequenceDFQKEVPSPRTSCPMGYKAYRSHCYALVMTPKSWFQADLVCQKRPSGHLVSILSGGEASFVSSLVNGRVDNYQDIWIGLHDPTMGQQPNGGGWEWSNSDVLNYLNWDGDPSSTVNRGHCGSLTASSGFLKWGDYYCDGTLPFVCKFKQ
Sequence map29-55
PDB IDNA
DrugpediaNA
ReceptorNA
DomainLacks the EPN motif and the presence of Gln instea
Pharmaceutical UseNA