Primary information |
---|
ID | 13424 |
Uniprot ID | O09037 |
Description | Regenerating islet-derived protein 3-alpha (REG-3-alpha) (Islet of Langerhans regenerating protein 3) (Lithostathine 3) (Pancreatitis-associated protein 2) (Regenerating islet-derived protein III-alpha) (Reg III-alpha) [Cleaved into- Regenerating islet-derived protein 3-alpha 16.5 kDa form; Regenera |
Organism | Mus musculus |
Txonomy | Eukaryota; Opisthokonta; Metazoa; Eumetazoa; Bilateria; Deuterostomia; Chordata; Craniata; Vertebrata; Gnathostomata (jawed vertebrates); Teleostomi; Euteleostomi; Sarcopterygii; Dipnotetrapodomorpha; Tetrapoda; Amniota; Mammalia; Theria; Eutheria; Boreoeutheria; Euarchontoglires; Glires (Rodents and rabbits); Rodentia; Myomorpha (mice and others); Muroidea; Muridae; Murinae; Mus; Mus; Mus musculus (Mouse) |
Subcellular Location | Secreted |
Developmental Stage | NA |
Similarity | NA |
Tissue Specificity | Small intestine and pancreas. |
Post Translational Modification | Proteolytic processing by trypsin removes an inhibitory N-terminal propeptide and is essential for its antimicrobial activity. |
Function | Bactericidal C-type lectin. Regulates keratinocyte proliferation and differentiation after skin injury via activation of EXTL3-PI3K-AKT signaling pathway. |
Length | 175 |
Molecular Weight | 19 |
Name | Regenerating islet-derived protein 3-alpha 16.5 kDa form |
Sequence | DFQKEVPSPRTSCPMGYKAYRSHCYALVMTPKSWFQADLVCQKRPSGHLVSILSGGEASFVSSLVNGRVDNYQDIWIGLHDPTMGQQPNGGGWEWSNSDVLNYLNWDGDPSSTVNRGHCGSLTASSGFLKWGDYYCDGTLPFVCKFKQ |
Sequence map | 29-55 |
PDB ID | NA |
Drugpedia | NA |
Receptor | NA |
Domain | Lacks the EPN motif and the presence of Gln instea |
Pharmaceutical Use | NA
|