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13417 details
Primary information
ID13417
Uniprot IDP35230
DescriptionRegenerating islet-derived protein 3-beta (REG-3-beta) (Pancreatitis-associated protein 1)
OrganismMus musculus
TxonomyEukaryota; Opisthokonta; Metazoa; Eumetazoa; Bilateria; Deuterostomia; Chordata; Craniata; Vertebrata; Gnathostomata (jawed vertebrates); Teleostomi; Euteleostomi; Sarcopterygii; Dipnotetrapodomorpha; Tetrapoda; Amniota; Mammalia; Theria; Eutheria; Boreoeutheria; Euarchontoglires; Glires (Rodents and rabbits); Rodentia; Myomorpha (mice and others); Muroidea; Muridae; Murinae; Mus; Mus; Mus musculus (Mouse)
Subcellular LocationSecreted Note=Found in the apical region of pancreatic acinar cells.
Developmental StageNA
SimilarityNA
Tissue SpecificityConstitutively expressed in the small intestine; moderately in colon and at an extremely low level in healthy pancreas.
Post Translational ModificationProteolytic processing by trypsin removes an inhibitory N-terminal propeptide and is essential for peptidoglycan binding and antibacterial activity.
FunctionBactericidal C-type lectin which acts against several intestinal Gram-positive and Gram-negative bacteria. Lacks antibacterial activity against S.typhimurium. May play a role in protection against infection with S.enteritidis by inhibiting its translocation from the gut lumen into intestinal tissues and further extraintestinal tissues.
Length175
Molecular Weight19
NameRegenerating islet-derived protein 3-beta 16.5 kDa form
SequenceDSLKNIPSARISCPKGSQAYGSYCYALFQIPQTWFDAELACQKRPGGHLVSVLNSAEASFLSSMVKRTGNSYQYTWIGLHDPTLGAEPNGGGWEWSNNDVMNYFNWERNPSTALDRAFCGSLSRASGFLKWRDMTCEVKLPYVCKFTG
Sequence map29-55
PDB IDNA
DrugpediaNA
ReceptorNA
DomainThe EPN motif is essential for recognition of the
Pharmaceutical UseNA