Detailed description page of Hmrbase2

This page displays user query in tabular form.

13410 details
Primary information
ID13410
Uniprot IDP27596
DescriptionNatriuretic peptides A (Atrial natriuretic factor prohormone)
OrganismCavia porcellus
TxonomyEukaryota; Opisthokonta; Metazoa; Eumetazoa; Bilateria; Deuterostomia; Chordata; Craniata; Vertebrata; Gnathostomata (jawed vertebrates); Teleostomi; Euteleostomi; Sarcopterygii; Dipnotetrapodomorpha; Tetrapoda; Amniota; Mammalia; Theria; Eutheria; Boreoeutheria; Euarchontoglires; Glires (Rodents and rabbits); Rodentia; Hystricomorpha; Caviidae (cavies); Cavia (guinea pigs); Cavia porcellus (Guinea pig)
Subcellular Location[Long-acting natriuretic peptide]- Secreted
Developmental StageAdult.
SimilarityBelongs to the natriuretic peptide family.
Tissue SpecificityNA
Post Translational ModificationThe precursor molecule is proteolytically cleaved by CORIN at Arg-98 to produce atrial natriuretic peptide. Undergoes further proteolytic cleavage by unknown proteases to give rise to long-acting natr
Function[Atrial natriuretic peptide]- Hormone that plays a key role in mediating cardio-renal homeostasis; and is involved in vascular remodeling and regulating energy metabolism. Acts by specifically binding and stimulating NPR1 to produce cGMP; which in turn activates effector proteins; such as PRKG1; that drive various biological responses. Regulates vasodilation; natriuresis; diuresis and aldosterone synthesis and is therefore essential for regulating blood pressure; controlling the extracellular fluid volume and maintaining the fluid-electrolyte balance. Also involved in inhibiting cardiac remodeling and cardiac hypertrophy by inducing cardiomyocyte apoptosis and attenuating the growth of cardiomyocytes and fibroblasts. Plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus; and thus prevents pregnancy-induced hypertension. In adipose tissue; acts in various cGMP- and PKG-dependent pathways to regulate lipid metabolism and energy homeosta
Length128
Molecular Weight13
NameNatriuretic peptides A
SequencePMYNVVSNADLVDFKNLLDHLEEKMPLEDEVVLPQVASEQNEEAGAVLSALPEVPSWPGEAGPAQREGGALGRGPWDSSDRSAPLKSKLRALLDAPRSLRRSSCFGGRMDRIGAQSSLGCNSFRYRR
Sequence map03-08
PDB IDNA
DrugpediaNA
ReceptorNA
DomainNA
Pharmaceutical UseNA