| Primary information |
|---|
| ID | 13380 |
| Uniprot ID | P18509 |
| Description | Pituitary adenylate cyclase-activating polypeptide (PACAP) [Cleaved into- PACAP-related peptide (PRP-48); Pituitary adenylate cyclase-activating polypeptide 27 (PACAP-27) (PACAP27); Pituitary adenylate cyclase-activating polypeptide 38 (PACAP-38) (PACAP38)] |
| Organism | Homo sapiens |
| Txonomy | Eukaryota; Opisthokonta; Metazoa; Eumetazoa; Bilateria; Deuterostomia; Chordata; Craniata; Vertebrata; Gnathostomata (jawed vertebrates); Teleostomi; Euteleostomi; Sarcopterygii; Dipnotetrapodomorpha; Tetrapoda; Amniota; Mammalia; Theria; Eutheria; Boreoeutheria; Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini; Hominoidea (apes); Hominidae (great apes); Homininae; Homo; Homo sapiens (Human) |
| Subcellular Location | Secreted |
| Developmental Stage | NA |
| Similarity | Belongs to the glucagon family. |
| Tissue Specificity | NA |
| Post Translational Modification | NA |
| Function | Binding to its receptor activates G proteins and stimulates adenylate cyclase in pituitary cells. Promotes neuron projection development through the RAPGEF2/Rap1/B-Raf/ERK pathway. In chromaffin cells; induces long-lasting increase of intracellular calcium concentrations and neuroendocrine secretion. Involved in the control of glucose homeostasis; induces insulin secretion by pancreatic beta cells. |
| Length | 176 |
| Molecular Weight | 18 |
| Name | Pituitary adenylate cyclase-activating polypeptide |
| Sequence | DVAHGILNEAYRKVLDQLSAGKHLQSLVARGVGGSLGGGAGDDAEPLS |
| Sequence map | 1152 |
| PDB ID | 1739432; 1730060; 14702039; 15489334; 2302217; 23800469; 8504103; 1483839; 11175907; 174708 |
| Drugpedia | 1GEA;2D2P;2JOD;6LPB;6M1I;6P9Y;6VN7; |
| Receptor | P32241; P41587 |
| Domain | NA |
| Pharmaceutical Use | NA
|