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13373 details
Primary information
ID13373
Uniprot IDP57774
DescriptionPro-neuropeptide Y [Cleaved into- Neuropeptide Y (Neuropeptide tyrosine) (NPY); C-flanking peptide of NPY (CPON)]
OrganismMus musculus
TxonomyEukaryota; Opisthokonta; Metazoa; Eumetazoa; Bilateria; Deuterostomia; Chordata; Craniata; Vertebrata; Gnathostomata (jawed vertebrates); Teleostomi; Euteleostomi; Sarcopterygii; Dipnotetrapodomorpha; Tetrapoda; Amniota; Mammalia; Theria; Eutheria; Boreoeutheria; Euarchontoglires; Glires (Rodents and rabbits); Rodentia; Myomorpha (mice and others); Muroidea; Muridae; Murinae; Mus; Mus; Mus musculus (Mouse)
Subcellular LocationSecreted Cytoplasmic vesicle; secretory vesicle; neuronal dense core vesicle
Developmental StageNA
SimilarityBelongs to the NPY family.
Tissue SpecificityOne of the most abundant peptides in the nervous system. Also found in some chromaffin cells of the adrenal medulla.
Post Translational ModificationThe neuropeptide Y form is cleaved at Pro-30 by the prolyl endopeptidase FAP (seprase) activity (in vitro).
FunctionNPY is implicated in the control of feeding and in secretion of gonadotrophin-release hormone.
Length97
Molecular Weight10
NamePro-neuropeptide Y
SequenceSSPETLISDLLMKESTENAPRTRLEDPSMW
Sequence map720
PDB ID16141072; 15489334; 11210195; 16452087; 21183079
DrugpediaNA
ReceptorNA
DomainNA
Pharmaceutical UseNA