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13370 details
Primary information
ID13370
Uniprot IDO35417
DescriptionProenkephalin-B (Beta-neoendorphin-dynorphin) (Preprodynorphin) [Cleaved into- Alpha-neoendorphin; Beta-neoendorphin; Big dynorphin (Big Dyn); Dynorphin A(1-17) (Dyn-A17) (Dynorphin A); Dynorphin A(1-13); Dynorphin A(1-8); Leu-enkephalin; Rimorphin (Dynorphin B) (Dyn-B) (Dynorphin B(1-13)); Leumorph
OrganismMus musculus
TxonomyEukaryota; Opisthokonta; Metazoa; Eumetazoa; Bilateria; Deuterostomia; Chordata; Craniata; Vertebrata; Gnathostomata (jawed vertebrates); Teleostomi; Euteleostomi; Sarcopterygii; Dipnotetrapodomorpha; Tetrapoda; Amniota; Mammalia; Theria; Eutheria; Boreoeutheria; Euarchontoglires; Glires (Rodents and rabbits); Rodentia; Myomorpha (mice and others); Muroidea; Muridae; Murinae; Mus; Mus; Mus musculus (Mouse)
Subcellular LocationSecreted
Developmental StageNA
SimilarityBelongs to the opioid neuropeptide precursor family.
Tissue SpecificityNA
Post Translational ModificationThe N-terminal domain contains 6 conserved cysteines thought to be involved in disulfide bonding and/or processing.
FunctionLeu-enkephalins compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions; including pain perception and responses to stress.
Length248
Molecular Weight28
NameProenkephalin-B
SequenceYGGFLRRQFKVVTRSQENPNTYSEDLDV
Sequence map672
PDB ID9751516; 2409273; 16292317
DrugpediaNA
ReceptorNA
DomainNA
Pharmaceutical UseNA