| Primary information |
|---|
| ID | 13243 |
| Uniprot ID | Q13519 |
| Description | Prepronociceptin [Cleaved into- Nocistatin; Nociceptin (Orphanin FQ) (PPNOC); Orphanin FQ2] |
| Organism | Homo sapiens |
| Txonomy | Eukaryota; Opisthokonta; Metazoa; Eumetazoa; Bilateria; Deuterostomia; Chordata; Craniata; Vertebrata; Gnathostomata (jawed vertebrates); Teleostomi; Euteleostomi; Sarcopterygii; Dipnotetrapodomorpha; Tetrapoda; Amniota; Mammalia; Theria; Eutheria; Boreoeutheria; Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini; Hominoidea (apes); Hominidae (great apes); Homininae; Homo; Homo sapiens (Human) |
| Subcellular Location | Secreted |
| Developmental Stage | NA |
| Similarity | Belongs to the opioid neuropeptide precursor family. |
| Tissue Specificity | Predominantly expressed in the brain and spinal cord. Also expressed and secreted by peripheral blood neutrophils following degranulation. |
| Post Translational Modification | Specific enzymatic cleavages at paired basic residues probably yield other active peptides besides nociceptin.; The N-terminal domain contains 6 conserved cysteines thought to be involved in disulfide |
| Function | [Nociceptin]- Ligand of the opioid receptor-like receptor OPRL1. It may act as a transmitter in the brain by modulating nociceptive and locomotor behavior. May be involved in neuronal differentiation and development. |
| Length | 176 |
| Molecular Weight | 20 |
| Name | Prepronociceptin |
| Sequence | FGGFTGARKSARKLANQ |
| Sequence map | 408 |
| PDB ID | 8710928; 8710930; 12950177; 14702039; 15489334; 9168905 |
| Drugpedia | NA |
| Receptor | P41146 |
| Domain | NA |
| Pharmaceutical Use | NA
|