Detailed description page of Hmrbase2

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13162 details
Primary information
ID13162
Uniprot IDC6EVG2
DescriptionExendin-2-long [Cleaved into- Exendin-2 (Helodermin) (VIP-like 2)]
OrganismHeloderma suspectum cinctum
TxonomyEukaryota; Opisthokonta; Metazoa; Eumetazoa; Bilateria; Deuterostomia; Chordata; Craniata; Vertebrata; Gnathostomata (jawed vertebrates); Teleostomi; Euteleostomi; Sarcopterygii; Dipnotetrapodomorpha; Tetrapoda; Amniota; Sauropsida; Sauria (diapsids); Lepidosauria (lepidosaurs); Squamata (squamates); Bifurcata (split-tongued squamates); Unidentata; Episquamata; Toxicofera; Anguimorpha (anguimorph lizards); Neoanguimorpha (New World anguimorph lizards); Helodermatidae (beaded lizards); Heloderma;
Subcellular LocationSecreted
Developmental StageNA
SimilarityBelongs to the glucagon family.
Tissue SpecificityExpressed by the venom gland.
Post Translational ModificationNA
FunctionHas vasoactive intestinal peptide(VIP)/secretin-like biological activity. Interacts with rat and human VIP receptors 1 (VIPR1) and 2 (VIPR2); with the highest affinity for the human VIPR2. Induces hypotension that is mediated by relaxation of cardiac smooth muscle.
Length84
Molecular Weight9
NameExendin-2-long
SequenceHSDAIFTEEYSKLLAKLALQKYLASILGSRTSPPP
Sequence map840
PDB ID19837656; 9928018; 15003357
DrugpediaNA
ReceptorNA
DomainNA
Pharmaceutical UseNA