| Primary information |
|---|
| ID | 13138 |
| Uniprot ID | P22387 |
| Description | Endothelin-1 (ET-1) (Preproendothelin-1) (PPET1) [Cleaved into- Big endothelin-1] |
| Organism | Mus musculus |
| Txonomy | Eukaryota; Opisthokonta; Metazoa; Eumetazoa; Bilateria; Deuterostomia; Chordata; Craniata; Vertebrata; Gnathostomata (jawed vertebrates); Teleostomi; Euteleostomi; Sarcopterygii; Dipnotetrapodomorpha; Tetrapoda; Amniota; Mammalia; Theria; Eutheria; Boreoeutheria; Euarchontoglires; Glires (Rodents and rabbits); Rodentia; Myomorpha (mice and others); Muroidea; Muridae; Murinae; Mus; Mus; Mus musculus (Mouse) |
| Subcellular Location | Secreted |
| Developmental Stage | Expression in lung is low at 17.5 dpc fetal mice and increases progressively into adulthood. |
| Similarity | Belongs to the endothelin/sarafotoxin family. |
| Tissue Specificity | Highest expression in the adult is in lung. Lower levels found in heart; kidney; brain and intestine. In the embryo; expressed in outer and inner pharyngeal arch surfaces. Also expressed in endotheliu |
| Post Translational Modification | NA |
| Function | Endothelins are endothelium-derived vasoconstrictor peptides. Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B; BCAR1; BCAR3 and; GTPases RAP1 and RHOA cascade in glomerular mesangial cells. |
| Length | 202 |
| Molecular Weight | 22 |
| Name | Endothelin-1 |
| Sequence | CSCSSLMDKECVYFCHLDIIW |
| Sequence map | 504 |
| PDB ID | 8575440; 8688455; 8824799; 15489334; 7883980; 8238383; 2768235; |
| Drugpedia | NA |
| Receptor | NA |
| Domain | NA |
| Pharmaceutical Use | NA
|