| Primary information |
|---|
| ID | 13078 |
| Uniprot ID | Q1MX22 |
| Description | FMRFamide-related peptides (FaRPs) (Bommo-FMRFamide) (BRFa) [Cleaved into- SAIDRSMIRF-amide (MIRFamide) (RFa-1); SASFVRF-amide (FVRFamide) (RFa-2); DPSFIRF-amide (FIRFamide) (RFa-3); ARNHFIRL-amide (FIRLamide) (RFa-4)] |
| Organism | Bombyx mori |
| Txonomy | Eukaryota; Opisthokonta; Metazoa; Eumetazoa; Bilateria; Protostomia; Ecdysozoa; Panarthropoda; Arthropoda; Mandibulata; Pancrustacea; Hexapoda; Insecta; Dicondylia; Pterygota (winged insects); Neoptera; Endopterygota; Amphiesmenoptera; Lepidoptera (butterflies and moths); Glossata; Neolepidoptera; Heteroneura; Ditrysia; Obtectomera; Bombycoidea (hawk-moths); Bombycidae (silkworm moths); Bombycinae; Bombyx; Bombyx mori (Silk moth) |
| Subcellular Location | Secreted |
| Developmental Stage | Expression is continuous throughout the developmental period; but is highest during the feeding period in the early half of the fifth instar stage (days 0-4). Expression decreases remarkably on day 5 |
| Similarity | Belongs to the FARP (FMRFamide related peptide) family. |
| Tissue Specificity | Only expressed in the CNS and predominantly in the thoracic ganglia. Strongest expression is seen in two pairs of large neurons in each thoracic ganglion. These neurons are ventrolateral neurosecretor |
| Post Translational Modification | NA |
| Function | Regulates ecdysteroidogenesis by direct innervation of the prothoracic gland by reducing cAMP production via the receptor for myosuppressin. The neurons that innervate the prothoracic gland during the fifth instar are most active during days 0-4; after which they reduce and then peak again on day 6. Expression suppresses the biosynthesis of steroid hormones called ecdysteroids that elicit molting and metamorphosis. |
| Length | 177 |
| Molecular Weight | 20 |
| Name | FMRFamide-related peptides |
| Sequence | ARNHFIRL |
| Sequence map | 192 |
| PDB ID | 16707581 |
| Drugpedia | NA |
| Receptor | NA |
| Domain | NA |
| Pharmaceutical Use | NA
|